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Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation.

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第一作者： Zizhang,Sheng

第一单位： Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, United States.;Department of Systems Biology, Columbia University, New York, NY, United States.

作者： Zizhang,Sheng ^[1] ; Chaim A,Schramm ^[2] ; Rui,Kong ^[3] ; NISC Comparative Sequencing Program ^[4] ; James C,Mullikin ^[3] ; John R,Mascola ^[5] ; Peter D,Kwong ^[2] ; Lawrence,Shapiro

作者单位： Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, United States.;Department of Systems Biology, Columbia University, New York, NY, United States. ^[1] Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, United States.;Department of Systems Biology, Columbia University, New York, NY, United States.;Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States. ^[2] Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States. ^[3] NIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, United States. ^[4] Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, United States.;Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States. ^[5]

关键词 B cell ontogeny antibodyomics broadly neutralizing antibody mutation frequency repertoire diversity

DOI 10.3389/fimmu.2017.00537

PMID 28539926

发布时间 2023-08-04

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