Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34.

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第一作者： Lucas,Robke

第一单位： Max-Planck-Institute of Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.

作者： Lucas,Robke ^[1] ; Luca,Laraia ^[2] ; Marjorie A,Carnero Corrales ^[1] ; Georgios,Konstantinidis ^[1] ; Makoto,Muroi ^[2] ; André,Richters ^[3] ; Michael,Winzker ^[4] ; Tobias,Engbring ^[5] ; Stefano,Tomassi ^[2] ; Nobumoto,Watanabe ^[1] ; Hiroyuki,Osada ^[2] ; Daniel,Rauh ^[2] ; Herbert,Waldmann ^[2] ; Yao-Wen,Wu ^[5] ; Julian,Engel ^[6]

作者单位： Max-Planck-Institute of Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany. ^[1] Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227, Dortmund, Germany. ^[2] Chemical Genomics Centre of the Max-Planck-Society, Otto-Hahn-Strasse 15, 44227, Dortmund, Germany. ^[3] Chemical Biology Research Group, RIKEN CSRS, 2-1, Hirosawa, Wako, Saitama, 351-0198, Japan. ^[4] RIKEN-Max Planck Joint Research Division for Systems Chemical Biology, RIKEN CSRS, 2-1, Hirosawa, Wako, Saitama, 351-0198, Japan. ^[5] Bio-Active Compounds Discovery Research Unit, RIKEN CSRS, 2-1, Hirosawa, Wako, Saitama, 351-0198, Japan. ^[6]

关键词 VPS34 aminopyrimidines autophagy kinase inhibitors phenotypic assays