T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model.
第一作者:
David M,Woods
第一单位:
H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL.
作者:
主题词
过继转移(Adoptive Transfer);动物(Animals);B-淋巴细胞(B-Lymphocytes);染色质(Chromatin);染色质免疫沉淀法(Chromatin Immunoprecipitation);疾病模型, 动物(Disease Models, Animal);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);移植物抗宿主病(Graft vs Host Disease);组蛋白脱乙酰基酶1(Histone Deacetylase 1);干扰素γ(Interferon-gamma);淋巴细胞活化(Lymphocyte Activation);淋巴瘤, B细胞(Lymphoma, B-Cell);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);启动区, 遗传(Promoter Regions, Genetic);信号传导(Signal Transduction);T盒域蛋白质类(T-Box Domain Proteins);T淋巴细胞(T-Lymphocytes);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)
DOI
10.1182/blood-2016-08-731505
PMID
28550044
发布时间
2023-06-10
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Blood
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