Extracellular heat shock protein 90α mediates HDM-induced bronchial epithelial barrier dysfunction by activating RhoA/MLC signaling.-论文-万方医学网

作者： Hang-Ming,Dong ^[1] ; Yan-Qing,Le ^[1] ; Yan-Hong,Wang ^[1] ; Hai-Jin,Zhao ^[1] ; Chao-Wen,Huang ^[1] ; Ya-Hui,Hu ^[1] ; Li-Shan,Luo ^[1] ; Xuan,Wan ^[1] ; Yi-Lan,Wei ^[1] ; Zi-Qiang,Chu ^[1] ; Wei,Li ^[2] ; Shao-Xi,Cai ^[3]

作者单位： Chronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, NanFang Hospital, Southern Medical University, Guangzhou, 510515, China. ^[1] Department of Dermatology and the Norris Comprehensive Cancer Centre, University of Southern California Keck, Medical Centre, Los Angeles, CA, 90033, USA. ^[2] Chronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, NanFang Hospital, Southern Medical University, Guangzhou, 510515, China. caishaox@fimmu.com. ^[3]

主题词动物(Animals);抗哮喘药(Anti-Asthmatic Agents);抗原, CD(Antigens, CD);支气管(Bronchi);钙黏着糖蛋白类(Cadherins);细胞系(Cell Line);右旋糖酐类(Dextrans);电阻抗(Electric Impedance);上皮细胞(Epithelial Cells);荧光素-5-异硫氰酸盐(Fluorescein-5-isothiocyanate);HSP90热休克蛋白质类(HSP90 Heat-Shock Proteins);人类(Humans);肌球蛋白轻链(Myosin Light Chains);通透性(Permeability);磷酰化(Phosphorylation);尘蟎科(Pyroglyphidae);RNA干扰(RNA Interference);信号传导(Signal Transduction);时间因素(Time Factors);转染(Transfection);β连环素(beta Catenin);rho相关激酶类(rho-Associated Kinases);ρA GTP结合蛋白质(rhoA GTP-Binding Protein)

DOI 10.1186/s12931-017-0593-y

PMID 28558721

发布时间 2018-12-02

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Extracellular heat shock protein 90α mediates HDM-induced bronchial epithelial barrier dysfunction by activating RhoA/MLC signaling.

Respiratory research

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Respiratory research

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Extracellular heat shock protein 90α mediates HDM-induced bronchial epithelial barrier dysfunction by activating RhoA/MLC signaling.

Respiratory research

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Respiratory research

相关期刊

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