作者:
Robert A,Scott [1]
;
Laura J,Scott [2]
;
Reedik,Mägi [3]
;
Letizia,Marullo [4]
;
Kyle J,Gaulton [5]
;
Marika,Kaakinen [6]
;
Natalia,Pervjakova [7]
;
Tune H,Pers [3]
;
Andrew D,Johnson [8]
;
John D,Eicher [9]
;
Anne U,Jackson [10]
;
Teresa,Ferreira [11]
;
Yeji,Lee [12]
;
Clement,Ma [12]
;
Valgerdur,Steinthorsdottir [2]
;
Gudmar,Thorleifsson [5]
;
Lu,Qi [2]
;
Natalie R,Van Zuydam [2]
;
Anubha,Mahajan [13]
;
Han,Chen [13]
;
Peter,Almgren [14]
;
Ben F,Voight [15]
;
Harald,Grallert [16]
;
Martina,Müller-Nurasyid [5]
;
Janina S,Ried [17]
;
Nigel W,Rayner [5]
;
Neil,Robertson [18]
;
Lennart C,Karssen [19]
;
Elisabeth M,van Leeuwen [20]
;
Sara M,Willems [21]
;
Christian,Fuchsberger [22]
;
Phoenix,Kwan [23]
;
Tanya M,Teslovich [24]
;
Pritam,Chanda [25]
;
Man,Li [26]
;
Yingchang,Lu [27]
;
Christian,Dina [28]
;
Dorothee,Thuillier [29]
;
Loic,Yengo [30]
;
Longda,Jiang [27]
;
Thomas,Sparso [5]
;
Hans A,Kestler [31]
;
Himanshu,Chheda [32]
;
Lewin,Eisele [5]
;
Stefan,Gustafsson [31]
;
Mattias,Frånberg [33]
;
Rona J,Strawbridge [34]
;
Rafn,Benediktsson [33]
;
Astradur B,Hreidarsson [1]
;
Augustine,Kong [33]
;
Gunnar,Sigurðsson [2]
;
Nicola D,Kerrison [2]
;
Jian'an,Luan [2]
;
Liming,Liang [35]
;
Thomas,Meitinger [36]
;
Michael,Roden [37]
;
Barbara,Thorand [38]
;
Tõnu,Esko [39]
;
Evelin,Mihailov [40]
;
Caroline,Fox [41]
;
Ching-Ti,Liu [40]
;
Denis,Rybin [41]
;
Bo,Isomaa [7]
;
Valeriya,Lyssenko [10]
;
Tiinamaija,Tuomi [42]
;
David J,Couper [43]
;
James S,Pankow [44]
;
Niels,Grarup [45]
;
Christian T,Have [46]
;
Marit E,Jørgensen [47]
;
Torben,Jørgensen [48]
;
Allan,Linneberg [49]
;
Marilyn C,Cornelis [47]
;
Rob M,van Dam [50]
;
David J,Hunter [51]
;
Peter,Kraft [51]
;
Qi,Sun [13]
;
Sarah,Edkins [51]
;
Katharine R,Owen [52]
;
John R B,Perry [1]
;
Andrew R,Wood [1]
;
Eleftheria,Zeggini [14]
;
Juan,Tajes-Fernandes [53]
;
Goncalo R,Abecasis [30]
;
Lori L,Bonnycastle [54]
;
Peter S,Chines [55]
;
Heather M,Stringham [26]
;
Heikki A,Koistinen [56]
;
Leena,Kinnunen [57]
;
Bengt,Sennblad [25]
;
Thomas W,Mühleisen [26]
;
Markus M,Nöthen [3]
;
Sonali,Pechlivanis [8]
;
Damiano,Baldassarre [58]
;
Karl,Gertow [3]
;
Steve E,Humphries [59]
;
Elena,Tremoli [60]
;
Norman,Klopp [61]
;
Julia,Meyer [62]
;
Gerald,Steinbach [63]
;
Roman,Wennauer [64]
;
Johan G,Eriksson [20]
;
Satu,Mӓnnistö [63]
;
Leena,Peltonen [65]
;
Emmi,Tikkanen [66]
;
Guillaume,Charpentier [67]
;
Elodie,Eury [10]
;
Stéphane,Lobbens [10]
;
Bruna,Gigante [68]
;
Karin,Leander [69]
;
Olga,McLeod [70]
;
Erwin P,Bottinger [71]
;
Omri,Gottesman [69]
;
Douglas,Ruderfer [72]
;
Matthias,Blüher [73]
;
Peter,Kovacs [74]
;
Anke,Tonjes [15]
;
Nisa M,Maruthur [75]
;
Chiara,Scapoli [14]
;
Raimund,Erbel [15]
;
Karl-Heinz,Jöckel [16]
;
Susanne,Moebus [76]
;
Ulf,de Faire [14]
;
Anders,Hamsten [53]
;
Michael,Stumvoll [76]
;
Panagiotis,Deloukas [15]
;
Peter J,Donnelly [16]
;
Timothy M,Frayling [32]
;
Andrew T,Hattersley [31]
;
Samuli,Ripatti [77]
;
Veikko,Salomaa [1]
;
Nancy L,Pedersen [78]
;
Bernhard O,Boehm [32]
;
Richard N,Bergman [5]
;
Francis S,Collins [2]
;
Karen L,Mohlke [79]
;
Jaakko,Tuomilehto [79]
;
Torben,Hansen [2]
;
Oluf,Pedersen [80]
;
Inês,Barroso [81]
;
Lars,Lannfelt [82]
;
Erik,Ingelsson [80]
;
Lars,Lind [81]
;
Cecilia M,Lindgren [82]
;
Stephane,Cauchi [47]
;
Philippe,Froguel [48]
;
Ruth J F,Loos [83]
;
Beverley,Balkau [84]
;
Heiner,Boeing [83]
;
Paul W,Franks [84]
;
Aurelio,Barricarte Gurrea [45]
;
Domenico,Palli [85]
;
Yvonne T,van der Schouw [86]
;
David,Altshuler [47]
;
Leif C,Groop [87]
;
Claudia,Langenberg [85]
;
Nicholas J,Wareham [86]
;
Eric,Sijbrands [24]
;
Cornelia M,van Duijn [88]
;
Jose C,Florez [27]
;
James B,Meigs [89]
;
Eric,Boerwinkle [90]
;
Christian,Gieger [63]
;
Konstantin,Strauch [91]
;
Andres,Metspalu [92]
;
Andrew D,Morris [93]
;
Colin N A,Palmer [91]
;
Frank B,Hu [32]
;
Unnur,Thorsteinsdottir [44]
;
Kari,Stefansson [91]
;
Josée,Dupuis [94]
;
Andrew P,Morris [44]
;
Michael,Boehnke [95]
;
Mark I,McCarthy [96]
;
Inga,Prokopenko [41]
;
DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium [41]
作者单位:
MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.
[1]
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI.
[2]
Estonian Genome Center, University of Tartu, Tartu, Estonia.
[3]
Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
[4]
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.
[5]
Department of Genetics, Stanford University, Stanford, CA.
[6]
Department of Genomics of Common Disease, Imperial College London, London, U.K.
[7]
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.
[8]
Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA.
[9]
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[10]
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
[11]
Framingham Heart Study, Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Framingham, MA.
[12]
deCODE genetics, Amgen, Inc., Reykjavik, Iceland.
[13]
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
[14]
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
[15]
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
[16]
Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics and Biomedical Research Institute, Ninewells Hospital, University of Dundee, Dundee, U.K.
[17]
Human Genetics Center and Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.
[18]
Center for Precision Health, School Biomedical Informatics, and School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.
[19]
Lund University Diabetes Centre and Department of Clinical Sciences Malmö, University Hospital Scania, Lund University, Malmö, Sweden.
[20]
Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
[21]
Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
[22]
Institute of Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
[23]
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
[24]
Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
[25]
German Center for Diabetes Research, Neuherberg, Germany.
[26]
Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
[27]
Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany.
[28]
Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.
[29]
Munich Heart Alliance, German Centre for Cardiovascular Disease, Munich, Germany.
[30]
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, U.K.
[31]
Wellcome Trust Sanger Institute, Hinxton, U.K.
[32]
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
[33]
PolyOmica, 's-Hertogenbosch, the Netherlands.
[34]
High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD.
[35]
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
[36]
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
[37]
The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY.
[38]
l'institut du thorax, INSERM, CNRS, Centre Hospitalier Universitaire de Nantes, Université de Nantes, Nantes, France.
[39]
Lille Institute of Biology, European Genomics Institute of Diabetes, Lille, France.
[40]
CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.
[41]
Leibniz Institute on Aging, Fritz Lipmann Institute, Jena, Germany.
[42]
Institute of Medical Systems Biology, Ulm University, Ulm, Germany.
[43]
Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
[44]
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, Germany.
[45]
Molecular Epidemiology, Department of Medical Sciences, and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
[46]
Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
[47]
Science for Life Laboratory, Stockholm, Sweden.
[48]
Department for Numerical Analysis and Computer Science, Stockholm University, Stockholm, Sweden.
[49]
Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
[50]
Landspítali University Hospital, Reykjavik, Iceland.
[51]
Icelandic Heart Association, Kópavogur, Iceland.
[52]
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA.
[53]
Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany.
[54]
Institute of Human Genetics, Technische Universität München, Munich, Germany.
[55]
Department of Endocrinology and Diabetology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
[56]
Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
[57]
Division of Genetics and Endocrinology, Boston Children's Hospital, Boston, MA.
[58]
Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA.
[59]
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
[60]
Department of Biostatistics, Boston University School of Public Health, Boston, MA.
[61]
Data Coordinating Center, Boston University School of Public Health, Boston, MA.
[62]
Folkhälsan Research Center, Helsinki, Finland.
[63]
Department of Social Services and Health Care, Jakobstad, Finland.
[64]
Department of Medicine, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
[65]
Collaborative Studies Coordinating Center, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC.
[66]
Division of Epidemiology & Community Health, University of Minnesota, Minneapolis, MN.
[67]
Steno Diabetes Center, Gentofte, Denmark.
[68]
Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark.
[69]
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[70]
Faculty of Medicine, Aalborg University, Aalborg, Denmark.
[71]
Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
[72]
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
[73]
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
[74]
Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
[75]
Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA.
[76]
National Institute for Health Research Oxford Biomedical Research Centre, Churchill Hospital, Oxford, U.K.
[77]
Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, U.K.
[78]
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
[79]
Department of Health, National Institute for Health and Welfare, Helsinki, Finland.
[80]
Endocrinology, Department of Medicine and Abdominal Center, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
[81]
Minerva Foundation Institute for Medical Research, Biomedicum Helsinki 2U, Helsinki, Finland.
[82]
Institute of Human Genetics, University of Bonn, Bonn, Germany.
[83]
Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
[84]
Centro Cardiologico Monzino, Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy.
[85]
Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy.
[86]
Cardiovascular Genetics, BHF Laboratories, Institute Cardiovascular Sciences, University College London, London, U.K.
[87]
Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.
[88]
Department of Clinical Chemistry and Central Laboratory, University of Ulm, Ulm, Germany.
[89]
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
[90]
Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
[91]
Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.
[92]
Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland.
[93]
Broad Institute of MIT and Harvard, Cambridge, MA.
[94]
Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland.
[95]
Endocrinology-Diabetology Unit, Corbeil-Essonnes Hospital, Corbeil-Essonnes, France.
[96]
Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
[97]
Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY.
[98]
IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.
[99]
Department of Medicine, University of Leipzig, Leipzig, Germany.
[100]
Division of General Internal Medicine, Department of Medicine, Johns Hopkins Bloomberg School of Medicine, Baltimore, MD.
[101]
The Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD.
[102]
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London, U.K.
[103]
Department of Statistics, University of Oxford, Oxford, U.K.
[104]
Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, U.K.
[105]
Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland.
[106]
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
[107]
Division of Endocrinology and Diabetes, Department of Internal Medicine, University Medical Centre Ulm, Ulm, Germany.
[108]
Lee Kong Chian School of Medicine, Imperial College London and Nanyang Technological University, Singapore, Singapore.
[109]
Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
[110]
Department of Genetics, University of North Carolina, Chapel Hill, NC.
[111]
Dasman Diabetes Institute, Dasman, Kuwait.
[112]
Centre for Vascular Prevention, Danube University Krems, Krems, Austria.
[113]
Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.
[114]
Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
[115]
University of Cambridge Metabolic Research Laboratories and National Institute for Health Research Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital Cambridge, Cambridge, U.K.
[116]
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
[117]
Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA.
[118]
Cardiovascular Epidemiology, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden.
[119]
The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
[120]
INSERM, CESP, UMR 1018, Villejuif, France.
[121]
University of Paris-Sud, UMR 1018, Villejuif, France.
[122]
German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
[123]
Lund University, Malmö, Sweden.
[124]
Umeå University, Umeå, Sweden.
[125]
Navarra Public Health Institute, Pamplona, Spain.
[126]
Navarra Institute for Health Research, Pamplona, Spain.
[127]
CIBER Epidemiology and Public Health, Madrid, Spain.
[128]
Cancer Research and Prevention Institute, Florence, Italy.
[129]
University Medical Center Utrecht, Utrecht, the Netherlands.
[130]
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA.
[131]
Department of Medicine, Harvard Medical School, Boston, MA.
[132]
Department of Genetics, Harvard Medical School, Boston, MA.
[133]
Department of Molecular Biology, Harvard Medical School, Boston, MA.
[134]
Diabetes Unit, Massachusetts General Hospital, Boston, MA.
[135]
Netherlands Genomics Initiative, Netherlands Consortium for Healthy Ageing and Center for Medical Systems Biology, Rotterdam, the Netherlands.
[136]
Diabetes Unit and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA.
[137]
General Medicine Division, Massachusetts General Hospital, Boston, MA.
[138]
Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, TX.
[139]
Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
[140]
Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
[141]
Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, U.K.
[142]
Cardiovascular and Diabetes Medicine, Biomedical Research Institute, Ninewells Hospital, University of Dundee, Dundee, U.K.
[143]
Department of Biostatistics, University of Liverpool, Liverpool, U.K.
[144]
Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, U.K.
[145]
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI boehnke@umich.edu.
[146]
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K. mark.mccarthy@drl.ox.ac.uk.
[147]
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K. i.prokopenko@imperial.ac.uk.
[148]
主题词
糖尿病, 2型(Diabetes Mellitus, Type 2);基因表达调控(Gene Expression Regulation);遗传变异(Genetic Variation);全基因组关联研究(Genome-Wide Association Study);人类(Humans)
DOI
10.2337/db16-1253
PMID
28566273
发布时间
2022-12-07
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Diabetes
Diabetes
2888-2902页
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