首页> Nucleosides, nucleotides & nucleic acids> A novel entecavir analogue constructing with a spiro[2.4]heptane core structure in the aglycon moiety: Its synthesis and evaluation for anti-hepatitis B virus activity.

A novel entecavir analogue constructing with a spiro[2.4]heptane core structure in the aglycon moiety: Its synthesis and evaluation for anti-hepatitis B virus activity.

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第一作者： Hiroki,Kumamoto

第一单位： a School of Pharmacy , Showa University , Shinagawa-ku , Tokyo , Japan.

作者： Hiroki,Kumamoto ^[1] ; Misato,Fukano ^[1] ; Shuhei,Imoto ^[2] ; Satoru,Kohgo ^[3] ; Yuki,Odanaka ^[1] ; Masayuki,Amano ^[4] ; Nobuyo,Kuwata-Higashi ^[3] ; Hiroaki,Mitsuya ^[5] ; Kazuhiro,Haraguchi ^[6] ; Kiyoshi,Fukuhara ^[1]

作者单位： a School of Pharmacy , Showa University , Shinagawa-ku , Tokyo , Japan. ^[1] b Faculty of Pharmaceutical Sciences , Sojo University , Kumamoto , Japan. ^[2] c Cinical Research Center, National Center for Global Health and Medicine , Tokyo , Japan. ^[3] d Departments of Infectious Diseases and Hematology , Kumamoto University School of Medicine , Kumamoto , Japan. ^[4] c Cinical Research Center, National Center for Global Health and Medicine , Tokyo , Japan.;d Departments of Infectious Diseases and Hematology , Kumamoto University School of Medicine , Kumamoto , Japan.;e Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute , National Institutes of Health , Bethesda , Maryland , USA. ^[5] f Nihon Pharmaceutical University , Saitama , Japan. ^[6]

关键词 Anti-HBV carbocyclic nucleoside entecavir radical-mediated cyclization spiro[2.4]heptane

医学主题词抗病毒药(Antiviral Agents);鸟嘌呤(Guanine);乙型肝炎病毒(Hepatitis B virus);庚烷类(Heptanes);构效关系(Structure-Activity Relationship)

DOI 10.1080/15257770.2017.1322209

PMID 28574799

发布时间 2025-05-30

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