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首页> Structure (London, England : 1993)> Mechanism-Informed Refinement Reveals Altered Substrate-Binding Mode for Catalytically Competent Nitroreductase.

Mechanism-Informed Refinement Reveals Altered Substrate-Binding Mode for Catalytically Competent Nitroreductase.

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作者： Warintra,Pitsawong ^[1] ; Chad A,Haynes ^[2] ; Ronald L,Koder ^[1] ; David W,Rodgers ^[3] ; Anne-Frances,Miller ^[4]

作者单位： Department of Chemistry, University of Kentucky, 505 Rose Street, Lexington, KY 40506-0055, USA. ^[1] Department of Molecular and Cellular Biochemistry and Center for Structural Biology, University of Kentucky, 741 South Limestone Street, Lexington, KY 40536-0509, USA. ^[2] Department of Molecular and Cellular Biochemistry and Center for Structural Biology, University of Kentucky, 741 South Limestone Street, Lexington, KY 40536-0509, USA. Electronic address: david.rodgers@uky.edu. ^[3] Department of Chemistry, University of Kentucky, 505 Rose Street, Lexington, KY 40506-0055, USA; Department of Molecular and Cellular Biochemistry and Center for Structural Biology, University of Kentucky, 741 South Limestone Street, Lexington, KY 40536-0509, USA. Electronic address: afmill3r2@gmail.com. ^[4]

关键词 flavoenzyme isotope effects nitroreductase prodrug activation remediation structure substrate binding mode

主题词细菌蛋白质类(Bacterial Proteins);结合部位(Binding Sites);阴沟肠杆菌(Enterobacter cloacae);黄素类(Flavins);NAD(NAD);硝基苯类(Nitrobenzoates);硝基还原酶类(Nitroreductases);蛋白质结合(Protein Binding);底物特异性(Substrate Specificity)

DOI 10.1016/j.str.2017.05.002

PMID 28578873

发布时间 2018-11-13

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Structure (London, England : 1993)

Structure (London, England

2017年25卷7期

978-987.e4页

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