Genetic risk score based on the prevalence of vertebral fracture in Japanese women with osteoporosis.

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第一作者： Heying,Zhou

第一单位： Center for the Promotion of Clinical Investigation, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.

作者： Heying,Zhou ^[1] ; Seijiro,Mori ^[1] ; Tatsuro,Ishizaki ^[2] ; Atsushi,Takahashi ^[3] ; Koichi,Matsuda ^[4] ; Yukihiro,Koretsune ^[5] ; Shiro,Minami ^[6] ; Masahiko,Higashiyama ^[7] ; Shinji,Imai ^[8] ; Kozo,Yoshimori ^[9] ; Minoru,Doita ^[10] ; Akira,Yamada ^[11] ; Satoshi,Nagayama ^[12] ; Kazuo,Kaneko ^[13] ; Satoshi,Asai ^[14] ; Masaki,Shiono ^[15] ; Michiaki,Kubo ^[16] ; Hideki,Ito ^[17]

作者单位： Center for the Promotion of Clinical Investigation, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan. ^[1] Research Team for Human Care, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan. ^[2] Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.;Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan. ^[3] Institute of Medical Science, The University of Tokyo, Tokyo, Japan. ^[4] National Hospital Organization, Osaka National Hospital, Osaka, Japan. ^[5] Department of Bioregulation, Institute for Advanced Medical Research, Nippon Medical School, Kawasaki, Japan. ^[6] Osaka Medical Center for Cancer & Cardiovascular Diseases, Osaka, Japan. ^[7] Department of Orthopaedic Surgery, Shiga University of Medical Science, Shiga, Japan. ^[8] Japan Anti-Tuberculosis Association, Fukujuji Hospital, Tokyo, Japan. ^[9] Department of Orthopedic Surgery, School of Medicine, Iwate Medical University, Morioka, Japan. ^[10] Clinical Trial Promotion Headquarters, Aso Iizuka Hospital, Tokyo, Japan. ^[11] Department of Gastroenterological Surgery, Cancer Institute Hospital, Tokyo, Japan. ^[12] Department of Orthopaedic Surgery, Juntendo University School of Medicine, Tokyo, Japan. ^[13] Division of Pharmacology, Nihon University School of Medicine, Tokyo, Japan. ^[14] Tokushukai Medical Corporation, Kanagawa, Japan. ^[15] Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan. ^[16] Local Independent Administrative Agency, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan. ^[17]

关键词 AUC, area under the curve BMD, bone mineral density CDKAL1, CDK5-regulatory subunit-associated protein 1-like 1 CI, confidence interval GPATCH1, G-patch domain-containing gene 1 GRS, genetic risk score GWAS, genome-wide association studies Genetic risk score OR, odds ratio Osteoporosis PKDCC, protein kinase domain containing, cytoplasmic ROC, receiver-operating characteristics SNP, single-nucleotide polymorphism Single-nucleotide polymorphism Vertebral fracture WNT16, wingless-type MMTV-integration site family member 16

DOI 10.1016/j.bonr.2016.07.001

PMID 28580384

发布时间 2022-03-31

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Genetic risk score based on the prevalence of vertebral fracture in Japanese women with osteoporosis.

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Genetic risk score based on the prevalence of vertebral fracture in Japanese women with osteoporosis.

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