An orthogonally protected CycloTriVeratrylene (CTV) as a highly pre-organized molecular scaffold for subsequent ligation of different cyclic peptides towards protein mimics.

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第一作者： Ondřej,Longin

第一单位： School of Chemistry, Joseph Black Building, University of Glasgow, University Avenue, Glasgow G12 8QQ, UK.

作者： Ondřej,Longin ^[1] ; Helmus,van de Langemheen ^[1] ; Rob M J,Liskamp ^[2]

作者单位： School of Chemistry, Joseph Black Building, University of Glasgow, University Avenue, Glasgow G12 8QQ, UK. ^[1] School of Chemistry, Joseph Black Building, University of Glasgow, University Avenue, Glasgow G12 8QQ, UK. Electronic address: Robert.liskamp@glasgow.ac.uk. ^[2]

关键词 Molecular scaffold Orthogonal functionalization Peptide cyclisation Protein mimic Synthetic antibody

主题词炔类(Alkynes);叠氮化合物(Azides);催化作用(Catalysis);铜(Copper);肽类, 环(Peptides, Cyclic);多环化合物(Polycyclic Compounds)

DOI 10.1016/j.bmc.2017.05.038

PMID 28583807

发布时间 2017-12-08

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