换一批
换一批Ca<sub>v</sub>1.2 channel current block by the PKA inhibitor H-89 in rat tail artery myocytes via a PKA-independent mechanism: Electrophysiological, functional, and molecular docking studies.
作者：
关键词
(S)-(-)-Bay K 8644 ((S)-(-)-methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)pyridine-5-carboxylate) (PubChem CID: 6603728)8-Bromoadenosine 3′,5′-cyclic monophosphate (PubChem CID: 32014)Ca(V)1.2 channelH-89H-89 (N-[2-[[3-(4-bromophenyl)-2-propen-1-yl]amino]ethyl]-5-isoquinolinesulfonamide) (PubChem CID: 449241)KT5720 ((9R,10S,12S)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-][1,6]benzodiazocine-10-carboxylic acid, hexyl ester) (PubChem CID: 3844)Molecular dockingN(6)-Benzoyladenosine-3′,5′-cyclic monophosphate (PubChem CID: 17757210)PKAPKA inhibitor fragment 6-22 (PubChem CID: 16155227)Patch-clampRat tail arteryVerapamil (PubChem CID: 62969)nifedipine (PubChem CID: 4485)
主题词
3-吡啶羧酸,1,4-二氢-2,6-二甲基-5-硝基-4-(2-(三氟甲基)苯基)-,甲酯(3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester);动物(Animals);结合部位(Binding Sites);钙通道阻滞药(Calcium Channel Blockers);钙通道, L型(Calcium Channels, L-Type);卡唑类(Carbazoles);细胞, 培养的(Cells, Cultured);环AMP依赖性蛋白激酶类(Cyclic AMP-Dependent Protein Kinases);电生理学现象(Electrophysiological Phenomena);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);异喹啉类(Isoquinolines);男(雄)性(Male);模型, 分子(Models, Molecular);肌, 平滑, 血管(Muscle, Smooth, Vascular);肌细胞, 平滑肌(Myocytes, Smooth Muscle);膜片钳术(Patch-Clamp Techniques);肽碎片(Peptide Fragments);蛋白激酶抑制剂(Protein Kinase Inhibitors);吡咯类(Pyrroles);大鼠, Wistar(Rats, Wistar);磺胺类(Sulfonamides);尾(Tail);血管舒张(Vasodilation)
DOI
10.1016/j.bcp.2017.05.020
PMID
28583845
发布时间
2018-02-01
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