首页> AAPS PharmSciTech> Discriminating Ability of Abbreviated Impactor Measurement Approach (AIM) to Detect Changes in Mass Median Aerodynamic Diameter (MMAD) of an Albuterol/Salbutamol pMDI Aerosol.

Discriminating Ability of Abbreviated Impactor Measurement Approach (AIM) to Detect Changes in Mass Median Aerodynamic Diameter (MMAD) of an Albuterol/Salbutamol pMDI Aerosol.

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第一作者： J,David Christopher

第一单位： Research CMC Statistics, Merck Research Laboratories, West Point, Pennsylvania, USA.

作者： J,David Christopher ^[1] ; Rajni B,Patel ^[2] ; Jolyon P,Mitchell ^[3] ; Terrence P,Tougas ^[4] ; Adrian P,Goodey ^[5] ; Jorge,Quiroz ^[1] ; Patrik U,Andersson ^[6] ; Svetlana,Lyapustina ^[7]

作者单位： Research CMC Statistics, Merck Research Laboratories, West Point, Pennsylvania, USA. ^[1] Independent consultant, Brookfield, Connecticut, USA. ^[2] Jolyon Mitchel Inhaler Consulting Services, Inc., London, Ontario, Canada. ^[3] Independent Consultant, New Milford, Connecticut, USA. ^[4] Biopharmaceutics and Specialty Dosage Forms, Merck & Co., Inc., Rahway, New Jersey, USA. ^[5] Pharmaceutical Technology & Development, AstraZeneca, Gothenburg, Sweden. ^[6] Pharmaceutical Practice Group, Drinker Biddle & Reath LLP, 1500 K Street, NW, Suite 1100, Washington DC, District of Columbia, 20005-1209, USA. svetlana.lyapustina@dbr.com. ^[7]

关键词 abbreviated impactor measurement efficient data analysis mass median aerodynamic diameter method sensitivity oral inhaler testing