Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer.
作者:
Alfonso,Urbanucci [1]
;
Stefan J,Barfeld [2]
;
Ville,Kytölä [3]
;
Harri M,Itkonen [2]
;
Ilsa M,Coleman [4]
;
Daniel,Vodák [5]
;
Liisa,Sjöblom [6]
;
Xia,Sheng [7]
;
Teemu,Tolonen [8]
;
Sarah,Minner [9]
;
Christoph,Burdelski [10]
;
Kati K,Kivinummi [3]
;
Annika,Kohvakka [6]
;
Steven,Kregel [11]
;
Mandeep,Takhar [12]
;
Mohammed,Alshalalfa [12]
;
Elai,Davicioni [12]
;
Nicholas,Erho [12]
;
Paul,Lloyd [13]
;
R Jeffrey,Karnes [14]
;
Ashley E,Ross [15]
;
Edward M,Schaeffer [16]
;
Donald J,Vander Griend [17]
;
Stefan,Knapp [18]
;
Eva,Corey [19]
;
Felix Y,Feng [20]
;
Peter S,Nelson [21]
;
Fahri,Saatcioglu [22]
;
Karen E,Knudsen [23]
;
Teuvo L J,Tammela [24]
;
Guido,Sauter [9]
;
Thorsten,Schlomm [25]
;
Matti,Nykter [3]
;
Tapio,Visakorpi [6]
;
Ian G,Mills [26]
作者单位:
Centre for Molecular Medicine Norway, Nordic European Molecular Biology Laboratory Partnership, Forskningsparken, University of Oslo, 21 0349 Oslo, Norway; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, 0424 Oslo, Norway. Electronic address: alfonsourbanucci@gmail.com.
[1]
Centre for Molecular Medicine Norway, Nordic European Molecular Biology Laboratory Partnership, Forskningsparken, University of Oslo, 21 0349 Oslo, Norway.
[2]
Prostate Cancer Research Center, Institute of Biosciences and Medical Technology (BioMediTech), University of Tampere and Tampere University of Technology, 33520 Tampere, Finland.
[3]
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
[4]
Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, 0424 Oslo, Norway.
[5]
Prostate Cancer Research Center, Institute of Biosciences and Medical Technology (BioMediTech), University of Tampere and Fimlab Laboratories, Tampere University Hospital, 33520 Tampere, Finland.
[6]
Department of Biosciences, University of Oslo, 0316 Oslo, Norway.
[7]
Department of Pathology, Fimlab Laboratories, Tampere University Hospital, 33520 Tampere, Finland.
[8]
University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
[9]
General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
[10]
Department of Surgery - Section of Urology, University of Chicago, Chicago, IL 60637, USA; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109-0940, USA.
[11]
Research and Development, GenomeDx Biosciences, Vancouver, BC V6B 1B8, Canada.
[12]
Department of Medicine, University of California at San Francisco, San Francisco, CA 94143-0410, USA; Helen Diller Comprehensive Cancer Center, University of California, San Francisco, CA 94143-0981, USA.
[13]
Department of Urology, Mayo Clinic, Rochester, MN 55902, USA.
[14]
Brady Urological Institute, Johns Hopkins Medical Institute, Baltimore, MD 21287, USA.
[15]
Department of Urology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Tarry 16-703, Chicago, IL 60611-3008, USA.
[16]
Department of Surgery - Section of Urology, University of Chicago, Chicago, IL 60637, USA.
[17]
Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, UK; Institute for Pharmaceutical Chemistry, Goethe-University Frankfurt, Campus Riedberg, Max-von Laue Strasse 9, 60438 Frankfurt am Main, Germany.
[18]
Department of Urology, University of Washington, Seattle, WA 98195, USA.
[19]
Department of Medicine, University of California at San Francisco, San Francisco, CA 94143-0410, USA; Helen Diller Comprehensive Cancer Center, University of California, San Francisco, CA 94143-0981, USA; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94115, USA.
[20]
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Urology, University of Washington, Seattle, WA 98195, USA; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
[21]
Department of Biosciences, University of Oslo, 0316 Oslo, Norway; Institute for Cancer Genetics and Informatics, Oslo University Hospital, 0424 Oslo, Norway.
[22]
Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
[23]
Prostate Cancer Research Center and Department of Urology, University of Tampere and Tampere University Hospital, 33014 Tampere, Finland.
[24]
Martini-Clinic, Prostate Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg 20095, Germany.
[25]
Centre for Molecular Medicine Norway, Nordic European Molecular Biology Laboratory Partnership, Forskningsparken, University of Oslo, 21 0349 Oslo, Norway; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, 0424 Oslo, Norway; PCUK Movember Centre of Excellence, CCRCB, Queen's University, Belfast BT7 1NN, Northern Ireland, UK. Electronic address: i.g.mills@ncmm.uio.no.
[26]
主题词
染色质(Chromatin);染色质组装和分解(Chromatin Assembly and Disassembly);DNA结合蛋白质类(DNA-Binding Proteins);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);男(雄)性(Male);肿瘤蛋白质类(Neoplasm Proteins);受体, 雄激素(Receptors, Androgen);转录因子(Transcription Factors)
DOI
10.1016/j.celrep.2017.05.049
PMID
28591577
发布时间
2022-01-29
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