Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity.-论文-万方医学网

第一作者： Meng,Xia

第一单位： National Key Laboratory of Medical Molecular Biology, Department of Immunology &Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China.

作者： Meng,Xia ^[1] ; Juan,Liu ^[2] ; Shuxun,Liu ^[2] ; Kun,Chen ^[3] ; Hongyu,Lin ^[3] ; Minghong,Jiang ^[1] ; Xiaoqing,Xu ^[1] ; Yiquan,Xue ^[2] ; Wei,Liu ^[1] ; Yan,Gu ^[2] ; Xiang,Zhang ^[2] ; Zhiqing,Li ^[3] ; Lin,Yi ^[2] ; Youcun,Qian ^[4] ; Chen,Zhou ^[5] ; Ru,Li ^[6] ; Xuan,Zhang ^[5] ; Zhanguo,Li ^[6] ; Xuetao,Cao ^[7]

作者单位： National Key Laboratory of Medical Molecular Biology, Department of Immunology &Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China. ^[1] National Key Laboratory of Medical Immunology &Institute of Immunology, Second Military Medical University, Shanghai 200433, China. ^[2] Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China. ^[3] Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China. ^[4] Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100032, China. ^[5] Department of Rheumatology &Immunology, Peking University People's Hospital, Beijing 100044, China. ^[6] National Key Laboratory of Medical Molecular Biology, Department of Immunology &Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China.;National Key Laboratory of Medical Immunology &Institute of Immunology, Second Military Medical University, Shanghai 200433, China. ^[7]

医学主题词成年人(Adult);老年人(Aged);动物(Animals);自身免疫(Autoimmunity);细胞极性(Cell Polarity);DNA结合蛋白质类(DNA-Binding Proteins);后成说, 遗传(Epigenesis, Genetic);基因表达调控(Gene Expression Regulation);基因沉默(Gene Silencing);组蛋白脱乙酰基酶1(Histone Deacetylase 1);组蛋白赖氨酸N-甲基转移酶(Histone-Lysine N-Methyltransferase);组蛋白类(Histones);人类(Humans);甲基化(Methylation);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);中年人(Middle Aged);启动区, 遗传(Promoter Regions, Genetic);Smad3蛋白质(Smad3 Protein);T淋巴细胞(T-Lymphocytes);T淋巴细胞, 调节性(T-Lymphocytes, Regulatory);转录因子(Transcription Factors);转化生长因子β(Transforming Growth Factor beta)

DOI 10.1038/ncomms15818

PMID 28598443

发布时间 2019-11-26

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Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity.

Nature communications

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Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity.

Nature communications

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同项目论文

Nature communications

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