Study protocol of a phase IB/II clinical trial of metformin and chloroquine in patients with <i>IDH1</i>-mutated or <i>IDH2</i>-mutated solid tumours.

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作者： Remco J,Molenaar ^[1] ; Robert J S,Coelen ^[2] ; Mohammed,Khurshed ^[3] ; Eva,Roos ^[1] ; Matthan W A,Caan ^[2] ; Myra E,van Linde ^[3] ; Mathilde,Kouwenhoven ^[4] ; Jos A M,Bramer ^[5] ; Judith V M G,Bovée ^[6] ; Ron A,Mathôt ^[7] ; Heinz-Josef,Klümpen ^[8] ; Hanneke W M,van Laarhoven ^[1] ; Cornelis J F,van Noorden ^[9] ; W Peter,Vandertop ^[10] ; Hans,Gelderblom ^[1] ; Thomas M,van Gulik ^[1] ; Johanna W,Wilmink ^[2]

作者单位： Department of Medical Oncology, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands. ^[1] Department of Medical Biology, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands. ^[2] Department of Experimental Surgery, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands. ^[3] Department of Radiology, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands. ^[4] Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands. ^[5] Department of Neurology, VU University Medical Centre, Amsterdam, The Netherlands. ^[6] Department of Orthopaedic Surgery, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands. ^[7] Department of Neurosurgery, Academic Medical Centre, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands. ^[8] Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. ^[9] Department of Clinical Pharmacology, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands. ^[10] Department of Neurosurgery, VU University Medical Centre, Amsterdam, The Netherlands. ^[11] Department of Medical Oncology, VU University Medical Centre, Amsterdam, The Netherlands. ^[12]

关键词 Adult oncology Clinical trials Hepatobiliary tumours Magnetic resonance imaging Neurological oncology Sarcoma