Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance.

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作者： Sydney M,Shaffer ^[1] ; Margaret C,Dunagin ^[2] ; Stefan R,Torborg ^[1] ; Eduardo A,Torre ^[1] ; Benjamin,Emert ^[3] ; Clemens,Krepler ^[1] ; Marilda,Beqiri ^[2] ; Katrin,Sproesser ^[2] ; Patricia A,Brafford ^[4] ; Min,Xiao ^[5] ; Elliott,Eggan ^[5] ; Ioannis N,Anastopoulos ^[5] ; Cesar A,Vargas-Garcia ^[5] ; Abhyudai,Singh ^[5] ; Katherine L,Nathanson ^[2] ; Meenhard,Herlyn ^[2] ; Arjun,Raj ^[6]

作者单位： Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. ^[1] Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. ^[2] Department of Biochemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. ^[3] Genomics and Computational Biology Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. ^[4] The Wistar Institute, Molecular and Cellular Oncogenesis Program, Melanoma Research Center, Philadelphia, Pennsylvania 19104, USA. ^[5] Electrical and Computer Engineering, University of Delaware, Newark, Delaware 19716, USA. ^[6] Biomedical Engineering, University of Delaware, Newark, Delaware 19716, USA. ^[7] Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. ^[8]