Cellular Stress in the Context of an Inflammatory Environment Supports TGF-β-Independent T Helper-17 Differentiation.

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作者： Verena,Brucklacher-Waldert ^[1] ; Cristina,Ferreira ^[2] ; Marisa,Stebegg ^[1] ; Olivier,Fesneau ^[3] ; Silvia,Innocentin ^[1] ; Julien C,Marie ^[4] ; Marc,Veldhoen ^[5]

作者单位： Laboratory for Lymphocyte Signalling and Development, The Babraham Institute, Cambridge CB22 3AT, UK. ^[1] Laboratory for Lymphocyte Signalling and Development, The Babraham Institute, Cambridge CB22 3AT, UK; Faculdade de Medicina da Universidade de Lisboa, Instituto de Medicina Molecular, Av. Professor Egas Moniz, Lisbon 1649-028, Portugal. ^[2] Immunology Virology and Inflammation Department, Cancer Research Center of Lyon UMR INSERM1052, CNRS 5286 28 rue Laennec, Lyon 69373, Cedex 08, France; Université Lyon 1, Lyon 69000, France; Centre Léon Bérard, Lyon 69008, France; Labex DEVweCAN, Lyon 69008, France. ^[3] Immunology Virology and Inflammation Department, Cancer Research Center of Lyon UMR INSERM1052, CNRS 5286 28 rue Laennec, Lyon 69373, Cedex 08, France; Université Lyon 1, Lyon 69000, France; Centre Léon Bérard, Lyon 69008, France; Labex DEVweCAN, Lyon 69008, France; TGFβ and Immuno-Evasion Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. ^[4] Laboratory for Lymphocyte Signalling and Development, The Babraham Institute, Cambridge CB22 3AT, UK; Faculdade de Medicina da Universidade de Lisboa, Instituto de Medicina Molecular, Av. Professor Egas Moniz, Lisbon 1649-028, Portugal. Electronic address: marc.veldhoen@medicina.ulisboa.pt. ^[5]

关键词 T cell activation T cell differentiation T helper cells Th17 cells autoimmunity cell stress interleukin-17 metabolic stress