Somatic mutations of the coding microsatellites within the beta-2-microglobulin gene in mismatch repair-deficient colorectal cancers and adenomas.

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第一作者： Mark,Clendenning

第一单位： Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia.

作者： Mark,Clendenning ^[1] ; Alvin,Huang ^[1] ; Harindra,Jayasekara ^[2] ; Marie,Lorans ^[3] ; Susan,Preston ^[4] ; Neil,O'Callaghan ^[1] ; Bernard J,Pope ^[1] ; Finlay A,Macrae ^[1] ; Ingrid M,Winship ^[5] ; Roger L,Milne ^[6] ; Graham G,Giles ^[7] ; Dallas R,English ^[8] ; John L,Hopper ^[7] ; Aung K,Win ^[8] ; Mark A,Jenkins ^[2] ; Melissa C,Southey ^[3] ; Christophe,Rosty ^[2] ; Daniel D,Buchanan ^[3] ; investigators from the Melbourne Collaborative Cohort Study and the Australasian Colorectal Cancer Family Registry Cohort ^[2]

作者单位： Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia. ^[1] Cancer Epidemiology Centre, Cancer Council Victoria, St Kilda, VIC, 3182, Australia. ^[2] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, 3010, Australia. ^[3] Centre for Alcohol Policy Research, La Trobe University, Melbourne, VIC, 3000, Australia. ^[4] Melbourne Bioinformatics, The University of Melbourne, Parkville, VIC, 3010, Australia. ^[5] Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Parkville, VIC, 3010, Australia. ^[6] Department of Medicine, The University of Melbourne, Parkville, VIC, 3010, Australia. ^[7] Genetic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, VIC, 3010, Australia. ^[8] Department of Epidemiology and Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, South Korea. ^[9] Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia. ^[10] Envoi Specialist Pathologists, Herston, QLD, 4006, Australia. ^[11] School of Medicine, University of Queensland, Herston, QLD, 4006, Australia. ^[12] Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia. daniel.buchanan@unimelb.edu.au. ^[13] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, 3010, Australia. daniel.buchanan@unimelb.edu.au. ^[14] Genetic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, VIC, 3010, Australia. daniel.buchanan@unimelb.edu.au. ^[15]

关键词 B2M Colorectal cancer Lynch syndrome MLH1 methylation Microsatellite instability Mismatch repair deficiency