Acquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption.-论文-万方医学网

第一作者： Stefan,Meyer

第一单位： Stem Cell &Leukaemia Proteomics Laboratory, Manchester Cancer Research Centre, Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine &Health, University of Manchester, Manchester, UK.;Manchester Academic Health Science Centre, Manchester, UK.;Department of Paediatric and Adolescent Oncology, Royal Manchester Children's Hospital, Manchester, UK.;Young Oncology Unit, Christie Hospital, Manchester, UK.

作者： Stefan,Meyer ^[1] ; Adam,Stevens ^[2] ; Roberto,Paredes ^[3] ; Marion,Schneider ^[3] ; Michael J,Walker ^[3] ; Andrew J K,Williamson ^[3] ; Maria-Belen,Gonzalez-Sanchez ^[3] ; Stephanie,Smetsers ^[4] ; Vineet,Dalal ^[3] ; Hsiang Ying,Teng ^[3] ; Daniel J,White ^[3] ; Sam,Taylor ^[3] ; Joanne,Muter ^[3] ; Andrew,Pierce ^[3] ; Chiara,de Leonibus ^[2] ; Davy A P,Rockx ^[4] ; Martin A,Rooimans ^[4] ; Elaine,Spooncer ^[3] ; Stacey,Stauffer ^[5] ; Kajal,Biswas ^[5] ; Barbara,Godthelp ^[6] ; Josephine,Dorsman ^[4] ; Peter E,Clayton ^[2] ; Shyam K,Sharan ^[5] ; Anthony D,Whetton ^[7]

作者单位： Stem Cell &Leukaemia Proteomics Laboratory, Manchester Cancer Research Centre, Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine &Health, University of Manchester, Manchester, UK.;Manchester Academic Health Science Centre, Manchester, UK.;Department of Paediatric and Adolescent Oncology, Royal Manchester Children's Hospital, Manchester, UK.;Young Oncology Unit, Christie Hospital, Manchester, UK. ^[1] Manchester Academic Health Science Centre, Manchester, UK.;Department of Paediatric Endocrinology, Faculty of Biology, Medicine &Health, University of Manchester, Manchester, UK. ^[2] Stem Cell &Leukaemia Proteomics Laboratory, Manchester Cancer Research Centre, Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine &Health, University of Manchester, Manchester, UK.;Manchester Academic Health Science Centre, Manchester, UK. ^[3] Department of Clinical Genetics, Section Oncogenetics, VU University Medical Center, Amsterdam, The Netherlands. ^[4] Mouse Cancer Genetics Program; Center for Cancer Research; Frederick National Laboratory for Cancer Research; National Cancer Institute, Frederick, MD, USA. ^[5] Department of Toxicogenetics, Leiden University Medical Center, Leiden, The Netherlands. ^[6] Stem Cell &Leukaemia Proteomics Laboratory, Manchester Cancer Research Centre, Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine &Health, University of Manchester, Manchester, UK.;Manchester Academic Health Science Centre, Manchester, UK.;Stoller Biomarker Discovery Centre, University of Manchester, Manchester, UK. ^[7]

医学主题词选择性剪接(Alternative Splicing);动物(Animals);BRCA2蛋白质(BRCA2 Protein);乳腺肿瘤(Breast Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);DNA损伤(DNA Damage);抗药性, 肿瘤(Drug Resistance, Neoplasm);外显子(Exons);范科尼贫血(Fanconi Anemia);女(雌)性(Female);基因, BRCA2(Genes, BRCA2);疾病遗传易感性(Genetic Predisposition to Disease);人类(Humans);内含子(Introns);K562细胞(K562 Cells);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);小鼠(Mice);突变(Mutation);肿瘤复发, 局部(Neoplasm Recurrence, Local);卵巢肿瘤(Ovarian Neoplasms);表型(Phenotype);RNA剪接(RNA Splicing);转录, 遗传(Transcription, Genetic)

DOI 10.1038/cddis.2017.264

PMID 28617445

发布时间 2025-05-30

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Acquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption.

Cell death & disease

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Acquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption.

Cell death & disease

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Cell death & disease

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