Critical Evaluation of Native Electrospray Ionization Mass Spectrometry for Fragment-Based Screening.

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第一作者： Melanie,Göth

第一单位： Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.

作者： Melanie,Göth ^[1] ; Volker,Badock ^[2] ; Jörg,Weiske ^[3] ; Kevin,Pagel ^[3] ; Benno,Kuropka ^[1]

作者单位： Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany. ^[1] Department of Molecular Physics, Fritz Haber Institute of the Max Planck Society, Faradayweg 4-6, 14195, Berlin, Germany. ^[2] Protein Technologies, Lead Discovery Berlin, Bayer AG, Müllerstraße 178, 13353, Berlin, Germany. ^[3] Institute of Chemistry and Biochemistry, Freie Universität Berlin, Thielallee 63, 14195, Berlin, Germany. ^[4]

关键词 analytical methods mass spectrometry noncovalent interactions protein-ligand complexes thermal shift assays

主题词高通量筛选分析(High-Throughput Screening Assays);蛋白质类(Proteins);光谱法, 质量, 电喷雾电离(Spectrometry, Mass, Electrospray Ionization);温度(Temperature)

DOI 10.1002/cmdc.201700177

PMID 28618179

发布时间 2019-12-10

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