DMT efficiently inhibits hepatic gluconeogenesis by regulating the Gαq signaling pathway.

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第一作者： Ting-Ting,Zhou

第一单位： Key Laboratory of Receptor ResearchShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.;University of Chinese Academy of SciencesBeijing, China.

作者： Ting-Ting,Zhou ^[1] ; Fei,Ma ^[2] ; Xiao-Fan,Shi ^[1] ; Xin,Xu ^[1] ; Te,Du ^[1] ; Xiao-Dan,Guo ^[1] ; Gai-Hong,Wang ^[3] ; Liang,Yu ^[1] ; Vatcharin,Rukachaisirikul ^[4] ; Li-Hong,Hu ^[5] ; Jing,Chen ^[5] ; Xu,Shen ^[6]

作者单位： Key Laboratory of Receptor ResearchShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.;University of Chinese Academy of SciencesBeijing, China. ^[1] School of PharmacyEast China University of Science and Technology, Shanghai, China. ^[2] Key Laboratory of Receptor ResearchShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. ^[3] Department of ChemistryFaculty of Science, Prince of Songkla University, Songkhla, Thailand. ^[4] Key Laboratory of Receptor ResearchShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China lhhu@simm.ac.cn jingchen@simm.ac.cn xshen@simm.ac.cn.;University of Chinese Academy of SciencesBeijing, China. ^[5] Key Laboratory of Receptor ResearchShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China lhhu@simm.ac.cn jingchen@simm.ac.cn xshen@simm.ac.cn.;University of Chinese Academy of SciencesBeijing, China.;Key Laboratory of Drug Target and Drug for Degenerative DiseaseSchool of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, China. ^[6]

关键词 Gαq signaling hepatic gluconeogenesis protein kinase B (AKT)type 2 diabetes mellitus (T2DM)