A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.

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第一作者： Sebastian,Dütting

第一单位： Institute of Experimental Biomedicine, University Hospital and University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.

作者： Sebastian,Dütting ^[1] ; Frederique,Gaits-Iacovoni ^[2] ; David,Stegner ^[3] ; Michael,Popp ^[1] ; Adrien,Antkowiak ^[1] ; Judith M M,van Eeuwijk ^[2] ; Paquita,Nurden ^[3] ; Simon,Stritt ^[1] ; Tobias,Heib ^[2] ; Katja,Aurbach ^[1] ; Oguzhan,Angay ^[4] ; Deya,Cherpokova ^[1] ; Niels,Heinz ^[2] ; Ayesha A,Baig ^[1] ; Maximilian G,Gorelashvili ^[2] ; Frank,Gerner ^[1] ; Katrin G,Heinze ^[2] ; Jerry,Ware ^[2] ; Georg,Krohne ^[1] ; Zaverio M,Ruggeri ^[2] ; Alan T,Nurden ^[5] ; Harald,Schulze ^[1] ; Ute,Modlich ^[2] ; Irina,Pleines ^[1] ; Cord,Brakebusch ^[2] ; Bernhard,Nieswandt ^[1]

作者单位： Institute of Experimental Biomedicine, University Hospital and University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany. ^[1] Rudolf Virchow Center, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany. ^[2] INSERM UMR1048, Institut des Maladies Métaboliques et Cardiovasculaires-I2MC, UMR1048, Institut National de la Santé et de la Recherche Médicale, Université de Toulouse, 1 Avenue Jean Poulhès, BP 84225, 31432 Toulouse Cedex 4, France. ^[3] Institut Hospitalo-Universitaire LIRYC, Plateforme Technologique d'Innovation Biomédicale, Hôpital Xavier Arnozan, Avenue du Haut Lévêque, 33604 Pessac, France. ^[4] Research Group for Gene Modification in Stem Cells, LOEWE Center for Cell and Gene Therapy Frankfurt/Main and the Paul-Ehrlich-Institute, Paul-Ehrlich-Straße 51-59, 63225 Langen, Germany. ^[5] Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, Arkansass 72205, USA. ^[6] Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany. ^[7] Department of Molecular Medicine, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, California 92037, USA. ^[8] BRIC, Biomedical Institute, University of Copenhagen, Nørregade 10, 1165 Copenhagen, Denmark. ^[9]

主题词动物(Animals);血小板(Blood Platelets);细胞极性(Cell Polarity);内皮细胞(Endothelial Cells);女(雌)性(Female);人类(Humans);巨核细胞(Megakaryocytes);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);血小板糖蛋白GPⅠb-Ⅸ复合物(Platelet Glycoprotein GPIb-IX Complex);cdc42 GTP结合蛋白质(cdc42 GTP-Binding Protein);ρA GTP结合蛋白质(rhoA GTP-Binding Protein)

DOI 10.1038/ncomms15838

PMID 28643773

发布时间 2019-04-26

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Nature communications

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A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.

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A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.

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