Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain.

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作者： Marion,Delenclos ^[1] ; Ayman H,Faroqi ^[1] ; Mei,Yue ^[1] ; Aishe,Kurti ^[1] ; Monica,Castanedes-Casey ^[1] ; Linda,Rousseau ^[1] ; Virginia,Phillips ^[1] ; Dennis W,Dickson ^[1] ; John D,Fryer ^[1] ; Pamela J,McLean ^[2]

作者单位： Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL, 32224, USA. ^[1] Neurobiology of Disease Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA. ^[2] Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL, 32224, USA. mclean.pamela@mayo.edu. ^[3] Neurobiology of Disease Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA. mclean.pamela@mayo.edu. ^[4]

关键词 Aggregation Alpha-synuclein Neonatal injection Viral vector model

主题词动物(Animals);动物, 新生(Animals, Newborn);星形细胞(Astrocytes);脑(Brain);依赖病毒(Dependovirus);疾病模型, 动物(Disease Models, Animal);遗传载体(Genetic Vectors);神经胶质增生(Gliosis);HEK293细胞(HEK293 Cells);人类(Humans);学习(Learning);记忆(Memory);小鼠, 近交C57BL(Mice, Inbred C57BL);小神经胶质细胞(Microglia);运动活动(Motor Activity);神经变性疾病(Neurodegenerative Diseases);α突触核蛋白(alpha-Synuclein)

DOI 10.1186/s40478-017-0455-3

PMID 28645308

发布时间 2023-08-04

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Acta neuropathologica communications

2017年5卷1期

51页

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Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain.

Acta neuropathologica communications

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Acta neuropathologica communications

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Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain.

Acta neuropathologica communications

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Acta neuropathologica communications

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