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Mutational Heterogeneity in <i>APC</i> and <i>KRAS</i> Arises at the Crypt Level and Leads to Polyclonality in Early Colorectal Tumorigenesis.

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第一作者: Mireia,Gausachs
第一单位: Hereditary Cancer Program, Catalan Institute of Oncology (ICO - IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
作者单位: Hereditary Cancer Program, Catalan Institute of Oncology (ICO - IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain. [1] Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas. [2] Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas.;Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas. [3] Hereditary Cancer Program, Catalan Institute of Oncology (ICO - IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.;CIBERONC, Instituto de Salud Carlos III, Madrid, Spain. [4] Cancer Prevention and Control Program, Catalan Institute of Oncology (ICO-IDIBELL) and CIBERESP, L'Hospitalet de Llobregat, Barcelona, Spain. [5] Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas. [6] Department of Pathology, University Hospital Bellvitge (HUB - IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain. [7] Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas. [8] Avera Institute for Human Genetics, Sioux Falls, South Dakota. [9] Cancer Prevention and Control Program, Catalan Institute of Oncology (ICO-IDIBELL) and CIBERESP, L'Hospitalet de Llobregat, Barcelona, Spain.;Department of Clinical Sciences, Medical School, University of Barcelona, Barcelona, Spain. [10] Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.;Clinical Cancer Genetics Program, The University of Texas MD Anderson Cancer Center, Houston, Texas. [11] Clinical Cancer Genetics Program, The University of Texas MD Anderson Cancer Center, Houston, Texas.;Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas. [12] Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas.;Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas. [13] Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas.;Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas. [14] Hereditary Cancer Program, Catalan Institute of Oncology (ICO - IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain. EVilar@mdanderson.org gcapella@iconcologia.net.;CIBERONC, Instituto de Salud Carlos III, Madrid, Spain. [15] Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas. EVilar@mdanderson.org gcapella@iconcologia.net.;Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas.;Clinical Cancer Genetics Program, The University of Texas MD Anderson Cancer Center, Houston, Texas.;Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. [16]
DOI 10.1158/1078-0432.CCR-17-0821
PMID 28645942
发布时间 2018-11-13
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Clinical cancer research : an official journal of the American Association for Cancer Research

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