miR-15b-5p resensitizes colon cancer cells to 5-fluorouracil by promoting apoptosis via the NF-κB/XIAP axis.-论文-万方医学网

作者： Ci,Zhao ^[1] ; Qi,Zhao ^[2] ; Chunhui,Zhang ^[1] ; Guangyu,Wang ^[2] ; Yuanfei,Yao ^[1] ; Xiaoyi,Huang ^[1] ; Fei,Zhan ^[1] ; Yuanyuan,Zhu ^[2] ; Jiaqi,Shi ^[3] ; Jianan,Chen ^[1] ; Feihu,Yan ^[1] ; Yanqiao,Zhang ^[1]

作者单位： Department of Gastrointestinal Medical Oncology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, 150000, China. ^[1] Translation Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, 150000, China. ^[2] Department of Biotherapy, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, 150000, China. ^[3] Department of Gastrointestinal Medical Oncology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, 150000, China. yanqiaozhang@ems.hrbmu.edu.cn. ^[4]

主题词动物(Animals);细胞凋亡(Apoptosis);碱基序列(Base Sequence);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);结肠肿瘤(Colonic Neoplasms);减量调节(Down-Regulation);抗药性, 肿瘤(Drug Resistance, Neoplasm);女(雌)性(Female);氟尿嘧啶(Fluorouracil);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);HEK293细胞(HEK293 Cells);人类(Humans);I-κB激酶(I-kappa B Kinase);小鼠, 裸(Mice, Nude);微RNAs(MicroRNAs);模型, 生物学(Models, Biological);NF-κB(NF-kappa B);信号传导(Signal Transduction);X连锁凋亡抑制蛋白质(X-Linked Inhibitor of Apoptosis Protein)

DOI 10.1038/s41598-017-04172-z

PMID 28646148

发布时间 2019-01-18

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miR-15b-5p resensitizes colon cancer cells to 5-fluorouracil by promoting apoptosis via the NF-κB/XIAP axis.

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miR-15b-5p resensitizes colon cancer cells to 5-fluorouracil by promoting apoptosis via the NF-κB/XIAP axis.

Scientific reports

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Scientific reports

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