The Structure of the R2TP Complex Defines a Platform for Recruiting Diverse Client Proteins to the HSP90 Molecular Chaperone System.

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作者： Angel,Rivera-Calzada ^[1] ; Mohinder,Pal ^[2] ; Hugo,Muñoz-Hernández ^[1] ; Juan R,Luque-Ortega ^[1] ; David,Gil-Carton ^[3] ; Gianluca,Degliesposti ^[4] ; J Mark,Skehel ^[4] ; Chrisostomos,Prodromou ^[5] ; Laurence H,Pearl ^[6] ; Oscar,Llorca ^[7]

作者单位： Centro de Investigaciones Biológicas (CIB), Spanish National Research Council (CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain. ^[1] Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9RQ, UK. ^[2] Structural Biology Unit, CIC bioGUNE, Bizkaia Technology Park, 48160 Derio, Spain. ^[3] MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. ^[4] Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9RQ, UK. Electronic address: chris.prodromou@sussex.ac.uk. ^[5] Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9RQ, UK. Electronic address: laurence.pearl@sussex.ac.uk. ^[6] Centro de Investigaciones Biológicas (CIB), Spanish National Research Council (CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain; Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain. Electronic address: ollorca@cnio.es. ^[7]

关键词 Hsp90 co-chaperone Pih1 R2TP complex Rvb1 Rvb2 Tah1 Tel2-Tti1-Tti2 cryo-electron microscopy (cryo-EM)