γ-Hydroxybutyric Acid (GHB) Pharmacokinetics and Pharmacodynamics: Semi-Mechanistic and Physiologically Relevant PK/PD Model.

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作者： Rutwij A,Dave ^[1] ; Kristin E,Follman ^[2] ; Marilyn E,Morris ^[1]

作者单位： Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, New York, 14214, USA. ^[1] Preclinical and Translational Pharmacokinetics and Pharmacodynamics (PTPK), Genentech Inc., South San Francisco, California, USA. ^[2] Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, New York, 14214, USA. memorris@buffalo.edu. ^[3]

关键词 PK/PD modeling and simulation active renal reabsorption active uptake into brain monocarboxylate transporters (MCTs)nonlinear PK semi-mechanistic kidney model γ-hydroxybutyric acid (GHB)

主题词脑(Brain);人类(Humans);羟丁酸盐类(Hydroxybutyrates);模型, 生物学(Models, Biological)

DOI 10.1208/s12248-017-0111-7

PMID 28653244

发布时间 2019-06-14

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