换一批
换一批Discovery of 5-methyl-2-(4-((4-(methylsulfonyl)benzyl)oxy)phenyl)-4-(piperazin-1-yl)pyrimidine derivatives as novel GRP119 agonists for the treatment of diabetes and obesity.
作者：
主题词
动物(Animals);体重(Body Weight);糖尿病, 2型(Diabetes Mellitus, Type 2);疾病模型, 动物(Disease Models, Animal);基因表达调控(Gene Expression Regulation);葡糖耐量试验(Glucose Tolerance Test);HEK293细胞(HEK293 Cells);人类(Humans);小鼠(Mice);分子结构(Molecular Structure);肥胖症(Obesity);嘧啶类(Pyrimidines);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);构效关系(Structure-Activity Relationship)
DOI
10.1007/s11030-017-9755-6
PMID
28656523
发布时间
2018-11-13
- 浏览14
Molecular diversity
637-654页
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