Identifying Subpopulations with Distinct Response to Treatment Using Plasma Biomarkers in Acute Heart Failure: Results from the PROTECT Trial : Differential Response in Acute Heart Failure.

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作者： Licette C Y,Liu ^[1] ; Mattia A E,Valente ^[1] ; Douwe,Postmus ^[2] ; Christopher M,O'Connor ^[3] ; Marco,Metra ^[4] ; Howard C,Dittrich ^[5] ; Piotr,Ponikowski ^[6] ; John R,Teerlink ^[7] ; Gad,Cotter ^[8] ; Beth,Davison ^[8] ; John G F,Cleland ^[9] ; Michael M,Givertz ^[10] ; Daniel M,Bloomfield ^[11] ; Dirk J,van Veldhuisen ^[1] ; Hans L,Hillege ^[1] ; Peter,van der Meer ^[2] ; Adriaan A,Voors ^[1]

作者单位： Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. ^[1] Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. ^[2] Inova Heart and Vascular Institute, Falls Church, VA, USA. ^[3] University of Brescia, Brescia, Italy. ^[4] Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, USA. ^[5] Medical University, Clinical Military Hospital, Wroclaw, Poland. ^[6] University of California at San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA. ^[7] Momentum Research, Durham, NC, USA. ^[8] Imperial College, London, UK. ^[9] Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA. ^[10] Merck Research Laboratories, Rahway, NJ, USA. ^[11] Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. A.A.Voors@umcg.nl. ^[12]

关键词 Acute heart failure Biomarkers Rolofylline Subpopulation treatment effect pattern plot Treatment heterogeneity