Characterization of forced degradation products of torasemide through MS tools and explanation of unusual losses observed during mass fragmentation of drug and degradation products through density functional theory.

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作者： Moolchand,Kurmi ^[1] ; Neha,Patel ^[2] ; Shalu,Jhajra ^[3] ; Prasad V,Bharatam ^[2] ; Saranjit,Singh ^[4]

作者单位： Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar 160 062, Punjab, India. ^[1] Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar 160 062, Punjab, India. ^[2] Analytical Development Group, Johnson and Johnson Pvt. Ltd., Mumbai 400080, Maharastra, India. ^[3] Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar 160 062, Punjab, India. Electronic address: ssingh@niper.ac.in. ^[4]

关键词 Degradation product Density functional theory Fragmentation behaviour High resolution mass spectrometry Multi-stage mass spectrometry Torasemide

主题词质谱分析法(Mass Spectrometry);分子量(Molecular Weight);磺胺类(Sulfonamides)

DOI 10.1016/j.jpba.2017.06.015

PMID 28666167

发布时间 2018-12-02

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