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首页> Biochemical pharmacology> Xenopus GLP-1-inspired discovery of novel GLP-1 receptor agonists as long-acting hypoglycemic and insulinotropic agents with significant therapeutic potential.

Xenopus GLP-1-inspired discovery of novel GLP-1 receptor agonists as long-acting hypoglycemic and insulinotropic agents with significant therapeutic potential.

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作者： Jing,Han ^[1] ; Xinyu,Chen ^[2] ; Yiyun,Wang ^[3] ; Yingying,Fei ^[2] ; Feng,Zhou ^[2] ; Ying,Zhang ^[2] ; Lin,Liu ^[2] ; Pengbin,Si ^[2] ; Junjie,Fu ^[4]

作者单位： School of Chemistry and Materials Science, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou 221116, PR China. Electronic address: hj1986424@jsnu.edu.cn. ^[1] School of Chemistry and Materials Science, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou 221116, PR China. ^[2] Gansu Institute for Drug Control, Lanzhou 730000, PR China. ^[3] Department of Medicinal Chemistry, School of Pharmacy, Nanjing Medical University, Nanjing 211166, PR China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: jfu@njmu.edu.cn. ^[4]

关键词 Exendin-4 (PubChem CID: 16157882)Glucagon-like peptide-1 Glucagon-like peptide-1 (PubChem CID: 16133831)Liraglutide (PubChem CID: 16134956)PEGylation Type 2 diabetes Xenopus GLP-1

主题词动物(Animals);血糖(Blood Glucose);克隆, 分子(Cloning, Molecular);糖尿病, 实验性(Diabetes Mellitus, Experimental);药物发现(Drug Discovery);胰高血糖素样肽1(Glucagon-Like Peptide 1);人类(Humans);降血糖药(Hypoglycemic Agents);男(雄)性(Male);小鼠, 近交系(Mice, Inbred Strains);爪蟾属(Xenopus)

DOI 10.1016/j.bcp.2017.06.132

PMID 28668697

发布时间 2018-02-02

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Biochemical pharmacology

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