Human neonatal thymectomy induces altered B-cell responses and autoreactivity.

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第一作者： Theo,van den Broek

第一单位： Laboratory of Translational Immunology, University Medical Center Utrecht/Wilhelmina Children's Hospital, Utrecht, The Netherlands.

作者： Theo,van den Broek ^[1] ; Asaf,Madi ^[2] ; Eveline M,Delemarre ^[1] ; Alvin W L,Schadenberg ^[3] ; Kiki,Tesselaar ^[1] ; José A M,Borghans ^[1] ; Stefan,Nierkens ^[1] ; Frank A,Redegeld ^[4] ; Henny G,Otten ^[1] ; Maura,Rossetti ^[5] ; Salvatore,Albani ^[5] ; Rachel,Sorek ^[6] ; Irun R,Cohen ^[2] ; Nicolaas J G,Jansen ^[7] ; Femke,van Wijk ^[1]

作者单位： Laboratory of Translational Immunology, University Medical Center Utrecht/Wilhelmina Children's Hospital, Utrecht, The Netherlands. ^[1] Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel. ^[2] Laboratory of Translational Immunology, University Medical Center Utrecht/Wilhelmina Children's Hospital, Utrecht, The Netherlands.;Department of Pediatric Intensive Care, Bristol Royal Hospital for Children, Bristol, UK. ^[3] Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands. ^[4] Duke-National University of Singapore Graduate Medical School, Singapore.;SingHealth Translational Immunology and Inflammation Centre, SingHealth, Singapore. ^[5] ImmunArray Ltd., Rehovot, Israel. ^[6] Department of Pediatric Intensive Care, University Medical Centre Utrecht, Utrecht, The Netherlands.;Department of Pediatric Cardiothoracic Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands. ^[7]

关键词 Autoimmunity B cells Homeostatic proliferation Lymphopenia Regulatory T cell Thymectomy