Small molecule metalloprotease inhibitor with in vitro, ex vivo and in vivo efficacy against botulinum neurotoxin serotype A.

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作者： Alan R,Jacobson ^[1] ; Michael,Adler ^[2] ; Nicholas R,Silvaggi ^[3] ; Karen N,Allen ^[3] ; Genessa M,Smith ^[1] ; Ross A,Fredenburg ^[4] ; Ross L,Stein ^[5] ; Jong-Beak,Park ^[6] ; Xiaochuan,Feng ^[6] ; Charles B,Shoemaker ^[6] ; Sharad S,Deshpande ^[7] ; Michael C,Goodnough ^[8] ; Carl J,Malizio ^[8] ; Eric A,Johnson ^[9] ; Sabine,Pellett ^[9] ; William H,Tepp ^[9] ; Saul,Tzipori ^[6]

作者单位： Absolute Science, Inc., Denver, CO, 80222, United States. ^[1] Neuroscience Branch, Medical Toxicology Division, USAMRICD, APG, MD, 21010, United States. Electronic address: michael.adler2.civ@mail.mil. ^[2] Department of Chemistry, Boston University, Boston, MA, 02215, United States. ^[3] Center for Neurologic Diseases, Brigham & Women's Hospital and Harvard Medical School, Cambridge, MA, 02139, United States. ^[4] Laboratory for Drug Discovery in Neurodegeneration, Brigham & Women's Hospital and Harvard Medical School, Cambridge, MA, 02139, United States. ^[5] Division of Infectious Diseases, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA, 01536, United States. ^[6] Neuroscience Branch, Medical Toxicology Division, USAMRICD, APG, MD, 21010, United States. ^[7] Metabiologics, Inc., Madison, WI, 53719, United States. ^[8] Department of Bacteriology, University of Wisconsin at Madison, Madison, WI, 53706, United States. ^[9]

关键词 Botulinum neurotoxin Botulinum toxin Botulism Mercaptoacetamide Metalloprotease inhibitor SNAP-25 SNARE protein X-ray crystallography