Golgi Outpost Synthesis Impaired by Toxic Polyglutamine Proteins Contributes to Dendritic Pathology in Neurons.

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作者： Chang Geon,Chung ^[1] ; Min Jee,Kwon ^[1] ; Keun Hye,Jeon ^[2] ; Do Young,Hyeon ^[3] ; Myeong Hoon,Han ^[1] ; Jeong Hyang,Park ^[1] ; In Jun,Cha ^[1] ; Jae Ho,Cho ^[1] ; Kunhyung,Kim ^[4] ; Sangchul,Rho ^[5] ; Gyu Ree,Kim ^[1] ; Hyobin,Jeong ^[5] ; Jae Won,Lee ^[6] ; TaeSoo,Kim ^[7] ; Keetae,Kim ^[4] ; Kwang Pyo,Kim ^[6] ; Michael D,Ehlers ^[8] ; Daehee,Hwang ^[9] ; Sung Bae,Lee ^[10]

作者单位： Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, Republic of Korea. ^[1] Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, Republic of Korea; Department of Family Medicine, Samsung Medical Center, Seoul 06351, Republic of Korea. ^[2] School of Interdisciplinary Bioscience and Bioengineering, POSTECH, Pohang 37673, Republic of Korea. ^[3] Department of New Biology, DGIST, Daegu 42988, Republic of Korea. ^[4] Center for Plant Aging Research, Institute for Basic Science, DGIST, Daegu 42988, Republic of Korea. ^[5] Department of Applied Chemistry, Institute of Natural Science, College of Applied Science, Kyung Hee University, Yongin 17104, Republic of Korea. ^[6] Department of Life Science and the Research Center for Cellular Homeostasis, Ewha Womans University, Seoul 03760, Republic of Korea. ^[7] Biogen, 225 Binney Street, Cambridge, MA 02142, USA. ^[8] School of Interdisciplinary Bioscience and Bioengineering, POSTECH, Pohang 37673, Republic of Korea; Department of New Biology, DGIST, Daegu 42988, Republic of Korea; Center for Plant Aging Research, Institute for Basic Science, DGIST, Daegu 42988, Republic of Korea. Electronic address: dhwang@dgist.ac.kr. ^[9] Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, Republic of Korea. Electronic address: sblee@dgist.ac.kr. ^[10]

关键词 CBP CREB3L1 CrebA Golgi outposts ataxin-3 dendrites neurodegeneration nuclear proteotoxicity polyQ