Dickkopf1 destabilizes atherosclerotic plaques and promotes plaque formation by inducing apoptosis of endothelial cells through activation of ER stress.
第一作者:
Mingxue,Di
第一单位:
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong University, Jinan 250012, China.
作者:
主题词
动物(Animals);主动脉(Aorta);载脂蛋白E类(Apolipoproteins E);细胞凋亡(Apoptosis);半胱氨酸天冬氨酸蛋白酶3(Caspase 3);细胞因子类(Cytokines);人类(Humans);胞间信号肽类和蛋白质类(Intercellular Signaling Peptides and Proteins);脂蛋白类, LDL(Lipoproteins, LDL);小鼠(Mice);丁酸苯酯类(Phenylbutyrates);斑块, 动脉粥样硬化(Plaque, Atherosclerotic);原癌基因蛋白质c-bcl-2(Proto-Oncogene Proteins c-bcl-2);RNA干扰(RNA Interference);唾液黏蛋白质类(Sialomucins);信号传导(Signal Transduction);转录因子CHOP(Transcription Factor CHOP);增量调节(Up-Regulation);bcl-2相关X蛋白质(bcl-2-Associated X Protein)
DOI
10.1038/cddis.2017.277
PMID
28703797
发布时间
2018-11-13
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Cell death & disease
e2917页
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