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Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.

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第一作者： Marta,Wlodarska

第一单位： The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.

作者： Marta,Wlodarska ^[1] ; Chengwei,Luo ^[2] ; Raivo,Kolde ^[3] ; Eva,d'Hennezel ^[4] ; John W,Annand ^[4] ; Cortney E,Heim ^[1] ; Philipp,Krastel ^[5] ; Esther K,Schmitt ^[5] ; Abdifatah S,Omar ^[6] ; Elizabeth A,Creasey ^[3] ; Ashley L,Garner ^[6] ; Sina,Mohammadi ^[4] ; Daniel J,O'Connell ^[6] ; Sahar,Abubucker ^[4] ; Timothy D,Arthur ^[6] ; Eric A,Franzosa ^[7] ; Curtis,Huttenhower ^[7] ; Leon O,Murphy ^[4] ; Henry J,Haiser ^[4] ; Hera,Vlamakis ^[6] ; Jeffrey A,Porter ^[4] ; Ramnik J,Xavier ^[8]

作者单位： The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA. ^[1] The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA. ^[2] Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA. ^[3] Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA. ^[4] Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland. ^[5] The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. ^[6] The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. ^[7] The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: xavier@molbio.mgh.harvard.edu. ^[8]

关键词 Muc2 Peptostreptococcus indoleacrylic acid indolepropionic acid mucus organoid