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Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain.

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第一作者： Geoffroy,Laumet

第一单位： Laboratory of Neuroimmunology, Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: GOLaumet@mdanderson.org.

作者： Geoffroy,Laumet ^[1] ; Wenjun,Zhou ^[2] ; Robert,Dantzer ^[3] ; Jules D,Edralin ^[4] ; XiaoJiao,Huo ^[5] ; David P,Budac ^[6] ; Jason C,O'Connor ^[7] ; Anna W,Lee ^[8] ; Cobi J,Heijnen ^[9] ; Annemieke,Kavelaars ^[10]

作者单位： Laboratory of Neuroimmunology, Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: GOLaumet@mdanderson.org. ^[1] Laboratory of Neuroimmunology, Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: Wenjun.Zhou@bcm.edu. ^[2] Laboratory of Neuroimmunology, Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: RDantzer@mdanderson.org. ^[3] Laboratory of Neuroimmunology, Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: JDEdralin@mdanderson.org. ^[4] Laboratory of Neuroimmunology, Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: XHuo@mdanderson.org. ^[5] Bioanalysis and Physiology, Lundbeck Research, Paramus, NJ, USA. Electronic address: dbudac@yahoo.com. ^[6] Department of Pharmacology, The University of Texas Health Science Center and Audie L. Murphy VA Hospital, South Texas Veteran's Heath Care System, San Antonio, TX, USA. Electronic address: oconnorj@uthscsa.edu. ^[7] Neuroinflammation Disease Biology Unit, Lundbeck Research USA, Paramus, NJ, USA(3). Electronic address: anna.newyork@gmail.com. ^[8] Laboratory of Neuroimmunology, Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: CJHeijnen@mdanderson.org. ^[9] Laboratory of Neuroimmunology, Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: AKavelaars@mdanderson.org. ^[10]

关键词 Comorbidity Depression Hippocampus Interleukin-1 Kynurenine 3-monooxygenase Kynurenine pathway Pain Psychoneuroimmunology Quinolinic acid