换一批Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
第一作者：
Rebecca,Sims
第一单位：
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
作者：
Rebecca,Sims [1]
;
Sven J,van der Lee [2]
;
Adam C,Naj [3]
;
Céline,Bellenguez [4]
;
Nandini,Badarinarayan [1]
;
Johanna,Jakobsdottir [5]
;
Brian W,Kunkle [6]
;
Anne,Boland [7]
;
Rachel,Raybould [1]
;
Joshua C,Bis [8]
;
Eden R,Martin [9]
;
Benjamin,Grenier-Boley [4]
;
Stefanie,Heilmann-Heimbach [10]
;
Vincent,Chouraki [11]
;
Amanda B,Kuzma [12]
;
Kristel,Sleegers [13]
;
Maria,Vronskaya [1]
;
Agustin,Ruiz [14]
;
Robert R,Graham [15]
;
Robert,Olaso [7]
;
Per,Hoffmann [16]
;
Megan L,Grove [17]
;
Badri N,Vardarajan [18]
;
Mikko,Hiltunen [19]
;
Markus M,Nöthen [10]
;
Charles C,White [20]
;
Kara L,Hamilton-Nelson [6]
;
Jacques,Epelbaum [21]
;
Wolfgang,Maier [22]
;
Seung-Hoan,Choi [23]
;
Gary W,Beecham [9]
;
Cécile,Dulary [7]
;
Stefan,Herms [16]
;
Albert V,Smith [24]
;
Cory C,Funk [25]
;
Céline,Derbois [7]
;
Andreas J,Forstner [10]
;
Shahzad,Ahmad [2]
;
Hongdong,Li [25]
;
Delphine,Bacq [7]
;
Denise,Harold [26]
;
Claudia L,Satizabal [11]
;
Otto,Valladares [12]
;
Alessio,Squassina [27]
;
Rhodri,Thomas [1]
;
Jennifer A,Brody [8]
;
Liming,Qu [12]
;
Pascual,Sánchez-Juan [28]
;
Taniesha,Morgan [1]
;
Frank J,Wolters [2]
;
Yi,Zhao [12]
;
Florentino Sanchez,Garcia [29]
;
Nicola,Denning [1]
;
Myriam,Fornage [30]
;
John,Malamon [12]
;
Maria Candida Deniz,Naranjo [29]
;
Elisa,Majounie [1]
;
Thomas H,Mosley [31]
;
Beth,Dombroski [12]
;
David,Wallon [32]
;
Michelle K,Lupton [33]
;
Josée,Dupuis [34]
;
Patrice,Whitehead [6]
;
Laura,Fratiglioni [35]
;
Christopher,Medway [36]
;
Xueqiu,Jian [30]
;
Shubhabrata,Mukherjee [37]
;
Lina,Keller [38]
;
Kristelle,Brown [36]
;
Honghuang,Lin [39]
;
Laura B,Cantwell [12]
;
Francesco,Panza [40]
;
Bernadette,McGuinness [41]
;
Sonia,Moreno-Grau [14]
;
Jeremy D,Burgess [42]
;
Vincenzo,Solfrizzi [43]
;
Petra,Proitsi [44]
;
Hieab H,Adams [2]
;
Mariet,Allen [42]
;
Davide,Seripa [45]
;
Pau,Pastor [46]
;
L Adrienne,Cupples [47]
;
Nathan D,Price [25]
;
Didier,Hannequin [48]
;
Ana,Frank-García [49]
;
Daniel,Levy [50]
;
Paramita,Chakrabarty [51]
;
Paolo,Caffarra [52]
;
Ina,Giegling [53]
;
Alexa S,Beiser [47]
;
Vilmantas,Giedraitis [54]
;
Harald,Hampel [55]
;
Melissa E,Garcia [56]
;
Xue,Wang [42]
;
Lars,Lannfelt [54]
;
Patrizia,Mecocci [46]
;
Gudny,Eiriksdottir [5]
;
Paul K,Crane [37]
;
Florence,Pasquier [57]
;
Virginia,Boccardi [46]
;
Isabel,Henández [14]
;
Robert C,Barber [58]
;
Martin,Scherer [59]
;
Lluis,Tarraga [14]
;
Perrie M,Adams [60]
;
Markus,Leber [61]
;
Yuning,Chen [34]
;
Marilyn S,Albert [62]
;
Steffi,Riedel-Heller [63]
;
Valur,Emilsson [64]
;
Duane,Beekly [65]
;
Anne,Braae [66]
;
Reinhold,Schmidt [67]
;
Deborah,Blacker [68]
;
Carlo,Masullo [69]
;
Helena,Schmidt [70]
;
Rachelle S,Doody [71]
;
Gianfranco,Spalletta [72]
;
W T,Longstreth [73]
;
Thomas J,Fairchild [74]
;
Paola,Bossù [72]
;
Oscar L,Lopez [75]
;
Matthew P,Frosch [76]
;
Eleonora,Sacchinelli [72]
;
Bernardino,Ghetti [77]
;
Qiong,Yang [34]
;
Ryan M,Huebinger [78]
;
Frank,Jessen [79]
;
Shuo,Li [34]
;
M Ilyas,Kamboh [80]
;
John,Morris [81]
;
Oscar,Sotolongo-Grau [14]
;
Mindy J,Katz [82]
;
Chris,Corcoran [83]
;
Melanie,Dunstan [1]
;
Amy,Braddel [1]
;
Charlene,Thomas [1]
;
Alun,Meggy [1]
;
Rachel,Marshall [1]
;
Amy,Gerrish [1]
;
Jade,Chapman [1]
;
Miquel,Aguilar [84]
;
Sarah,Taylor [1]
;
Matt,Hill [1]
;
Mònica Díez,Fairén [85]
;
Angela,Hodges [86]
;
Bruno,Vellas [87]
;
Hilkka,Soininen [88]
;
Iwona,Kloszewska [89]
;
Makrina,Daniilidou [90]
;
James,Uphill [91]
;
Yogen,Patel [44]
;
Joseph T,Hughes [44]
;
Jenny,Lord [36]
;
James,Turton [36]
;
Annette M,Hartmann [53]
;
Roberta,Cecchetti [46]
;
Chiara,Fenoglio [92]
;
Maria,Serpente [92]
;
Marina,Arcaro [92]
;
Carlo,Caltagirone [72]
;
Maria Donata,Orfei [72]
;
Antonio,Ciaramella [72]
;
Sabrina,Pichler [93]
;
Manuel,Mayhaus [93]
;
Wei,Gu [93]
;
Alberto,Lleó [94]
;
Juan,Fortea [94]
;
Rafael,Blesa [94]
;
Imelda S,Barber [66]
;
Keeley,Brookes [66]
;
Chiara,Cupidi [95]
;
Raffaele Giovanni,Maletta [95]
;
David,Carrell [96]
;
Sandro,Sorbi [97]
;
Susanne,Moebus [98]
;
Maria,Urbano [45]
;
Alberto,Pilotto [45]
;
Johannes,Kornhuber [99]
;
Paolo,Bosco [100]
;
Stephen,Todd [41]
;
David,Craig [41]
;
Janet,Johnston [41]
;
Michael,Gill [101]
;
Brian,Lawlor [101]
;
Aoibhinn,Lynch [101]
;
Nick C,Fox [102]
;
John,Hardy [102]
;
ARUK Consortium [103]
;
Roger L,Albin [104]
;
Liana G,Apostolova [105]
;
Steven E,Arnold [106]
;
Sanjay,Asthana [106]
;
Craig S,Atwood [107]
;
Clinton T,Baldwin [108]
;
Lisa L,Barnes [18]
;
Sandra,Barral [109]
;
Thomas G,Beach [110]
;
James T,Becker [111]
;
Eileen H,Bigio [112]
;
Thomas D,Bird [113]
;
Bradley F,Boeve [114]
;
James D,Bowen [115]
;
Adam,Boxer [116]
;
James R,Burke [117]
;
Jeffrey M,Burns [118]
;
Joseph D,Buxbaum [119]
;
Nigel J,Cairns [120]
;
Chuanhai,Cao [121]
;
Chris S,Carlson [122]
;
Cynthia M,Carlsson [123]
;
Regina M,Carney [42]
;
Minerva M,Carrasquillo [124]
;
Steven L,Carroll [51]
;
Carolina Ceballos,Diaz [125]
;
Helena C,Chui [126]
;
David G,Clark [127]
;
David H,Cribbs [123]
;
Elizabeth A,Crocco [128]
;
Charles,DeCarli [129]
;
Malcolm,Dick [130]
;
Ranjan,Duara [131]
;
Denis A,Evans [132]
;
Kelley M,Faber [133]
;
Kenneth B,Fallon [134]
;
David W,Fardo [135]
;
Martin R,Farlow [136]
;
Steven,Ferris [132]
;
Tatiana M,Foroud [137]
;
Douglas R,Galasko [138]
;
Marla,Gearing [139]
;
Daniel H,Geschwind [9]
;
John R,Gilbert [140]
;
Neill R,Graff-Radford [141]
;
Robert C,Green [142]
;
John H,Growdon [143]
;
Ronald L,Hamilton [144]
;
Lindy E,Harrell [145]
;
Lawrence S,Honig [146]
;
Matthew J,Huentelman [147]
;
Christine M,Hulette [142]
;
Bradley T,Hyman [148]
;
Gail P,Jarvik [149]
;
Erin,Abner [150]
;
Lee-Way,Jin [151]
;
Gyungah,Jun [115]
;
Anna,Karydas [152]
;
Jeffrey A,Kaye [153]
;
Ronald,Kim [154]
;
Neil W,Kowall [155]
;
Joel H,Kramer [156]
;
Frank M,LaFerla [157]
;
James J,Lah [158]
;
James B,Leverenz [157]
;
Allan I,Levey [159]
;
Ge,Li [160]
;
Andrew P,Lieberman [161]
;
Kathryn L,Lunetta [162]
;
Constantine G,Lyketsos [144]
;
Daniel C,Marson [163]
;
Frank,Martiniuk [164]
;
Deborah C,Mash [165]
;
Eliezer,Masliah [37]
;
Wayne C,McCormick [166]
;
Susan M,McCurry [121]
;
Andrew N,McDavid [154]
;
Ann C,McKee [167]
;
Marsel,Mesulam [115]
;
Bruce L,Miller [168]
;
Carol A,Miller [150]
;
Joshua W,Miller [169]
;
John C,Morris [170]
;
Jill R,Murrell [123]
;
Amanda J,Myers [171]
;
Sid,O'Bryant [128]
;
John M,Olichney [172]
;
Vernon S,Pankratz [173]
;
Joseph E,Parisi [174]
;
Henry L,Paulson [6]
;
William,Perry [96]
;
Elaine,Peskind [127]
;
Aimee,Pierce [129]
;
Wayne W,Poon [175]
;
Huntington,Potter [152]
;
Joseph F,Quinn [120]
;
Ashok,Raj [96]
;
Murray,Raskind [176]
;
Barry,Reisberg [177]
;
Christiane,Reitz [178]
;
John M,Ringman [144]
;
Erik D,Roberson [179]
;
Ekaterina,Rogaeva [115]
;
Howard J,Rosen [180]
;
Roger N,Rosenberg [181]
;
Mark A,Sager [182]
;
Andrew J,Saykin [183]
;
Julie A,Schneider [184]
;
Lon S,Schneider [115]
;
William W,Seeley [120]
;
Amanda G,Smith [185]
;
Joshua A,Sonnen [77]
;
Salvatore,Spina [186]
;
Robert A,Stern [117]
;
Russell H,Swerdlow [142]
;
Rudolph E,Tanzi [187]
;
Tricia A,Thornton-Wells [188]
;
John Q,Trojanowski [189]
;
Juan C,Troncoso [188]
;
Vivianna M,Van Deerlin [190]
;
Linda J,Van Eldik [191]
;
Harry V,Vinters [192]
;
Jean Paul,Vonsattel [193]
;
Sandra,Weintraub [194]
;
Kathleen A,Welsh-Bohmer [195]
;
Kirk C,Wilhelmsen [145]
;
Jennifer,Williamson [157]
;
Thomas S,Wingo [196]
;
Randall L,Woltjer [197]
;
Clinton B,Wright [37]
;
Chang-En,Yu [198]
;
Lei,Yu [7]
;
Fabienne,Garzia [7]
;
Feroze,Golamaully [7]
;
Gislain,Septier [199]
;
Sebastien,Engelborghs [200]
;
Rik,Vandenberghe [199]
;
Peter P,De Deyn [29]
;
Carmen Muñoz,Fernadez [29]
;
Yoland Aladro,Benito [201]
;
Hakan,Thonberg [201]
;
Charlotte,Forsell [201]
;
Lena,Lilius [201]
;
Anne,Kinhult-Stählbom [54]
;
Lena,Kilander [54]
;
RoseMarie,Brundin [52]
;
Letizia,Concari [202]
;
Seppo,Helisalmi [202]
;
Anne Maria,Koivisto [202]
;
Annakaisa,Haapasalo [203]
;
Vincent,Dermecourt [204]
;
Nathalie,Fievet [205]
;
Olivier,Hanon [206]
;
Carole,Dufouil [207]
;
Alexis,Brice [208]
;
Karen,Ritchie [209]
;
Bruno,Dubois [210]
;
Jayanadra J,Himali [185]
;
C Dirk,Keene [83]
;
JoAnn,Tschanz [211]
;
Annette L,Fitzpatrick [212]
;
Walter A,Kukull [83]
;
Maria,Norton [213]
;
Thor,Aspelund [214]
;
Eric B,Larson [83]
;
Ron,Munger [215]
;
Jerome I,Rotter [82]
;
Richard B,Lipton [216]
;
María J,Bullido [2]
;
Albert,Hofman [185]
;
Thomas J,Montine [217]
;
Eliecer,Coto [218]
;
Eric,Boerwinkle [113]
;
Ronald C,Petersen [217]
;
Victoria,Alvarez [219]
;
Fernando,Rivadeneira [220]
;
Eric M,Reiman [95]
;
Maura,Gallo [221]
;
Christopher J,O'Donnell [222]
;
Joan S,Reisch [95]
;
Amalia Cecilia,Bruni [223]
;
Donald R,Royall [224]
;
Martin,Dichgans [225]
;
Mary,Sano [92]
;
Daniela,Galimberti [226]
;
Peter,St George-Hyslop [92]
;
Elio,Scarpini [159]
;
Debby W,Tsuang [227]
;
Michelangelo,Mancuso [227]
;
Ubaldo,Bonuccelli [228]
;
Ashley R,Winslow [229]
;
Antonio,Daniele [230]
;
Chuang-Kuo,Wu [231]
;
GERAD/PERADES, CHARGE, ADGC, EADI [97]
;
Oliver,Peters [93]
;
Benedetta,Nacmias [232]
;
Matthias,Riemenschneider [233]
;
Reinhard,Heun [234]
;
Carol,Brayne [235]
;
David C,Rubinsztein [235]
;
Jose,Bras [236]
;
Rita,Guerreiro [236]
;
Ammar,Al-Chalabi [91]
;
Christopher E,Shaw [237]
;
John,Collinge [238]
;
David,Mann [94]
;
Magda,Tsolaki [239]
;
Jordi,Clarimón [240]
;
Rebecca,Sussams [1]
;
Simon,Lovestone [1]
;
Michael C,O'Donovan [15]
;
Michael J,Owen [91]
;
Timothy W,Behrens [241]
;
Simon,Mead [242]
;
Alison M,Goate [243]
;
Andre G,Uitterlinden [81]
;
Clive,Holmes [54]
;
Carlos,Cruchaga [198]
;
Martin,Ingelsson [44]
;
David A,Bennett [244]
;
John,Powell [245]
;
Todd E,Golde [246]
;
Caroline,Graff [36]
;
Philip L,De Jager [140]
;
Kevin,Morgan [28]
;
Nilufer,Ertekin-Taner [247]
;
Onofre,Combarros [41]
;
Bruce M,Psaty [140]
;
Peter,Passmore [248]
;
Steven G,Younkin [24]
;
Claudine,Berr [53]
;
Vilmundur,Gudnason [42]
;
Dan,Rujescu [249]
;
Dennis W,Dickson [47]
;
Jean-François,Dartigues [250]
;
Anita L,DeStefano [251]
;
Sara,Ortega-Cubero [32]
;
Hakon,Hakonarson [14]
;
Dominique,Campion [252]
;
Merce,Boada [253]
;
John Keoni,Kauwe [13]
;
Lindsay A,Farrer [254]
;
Christine,Van Broeckhoven [1]
;
M Arfan,Ikram [255]
;
Lesley,Jones [256]
;
Jonathan L,Haines [56]
;
Christophe,Tzourio [1]
;
Lenore J,Launer [18]
;
Valentina,Escott-Price [7]
;
Richard,Mayeux [2]
;
Jean-François,Deleuze [1]
;
Najaf,Amin [9]
;
Peter A,Holmans [257]
;
Margaret A,Pericak-Vance [2]
;
Philippe,Amouyel [258]
;
Cornelia M,van Duijn [12]
;
Alfredo,Ramirez [4]
;
Li-San,Wang [11]
;
Jean-Charles,Lambert [1]
;
Sudha,Seshadri [12]
;
Julie,Williams ;
Gerard D,Schellenberg
作者单位：
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
[1]
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
[2]
Department of Biostatistics and Epidemiology/Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
[3]
INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.;Institut Pasteur de Lille, Lille, France.;University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.
[4]
Icelandic Heart Association, Kopavogur, Iceland.
[5]
John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
[6]
CEA/Institut de Génomique, Centre National de Génotypage, Evry, France.
[7]
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
[8]
John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.;Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA.
[9]
Institute of Human Genetics, University of Bonn, Bonn, Germany.;Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany.
[10]
Boston University School of Medicine, Boston, Massachusetts, USA.;Framingham Heart Study, Framingham, Massachusetts, USA.
[11]
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
[12]
Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium.;Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
[13]
Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain.
[14]
Immunology Biomarkers Group, Genentech, South San Francisco, California, USA.
[15]
Institute of Human Genetics, University of Bonn, Bonn, Germany.;Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany.;Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, Switzerland.
[16]
School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA.
[17]
Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.;Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.;Department of Neurology, Columbia University, New York, New York, USA.
[18]
Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.;Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
[19]
Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.
[20]
UMR 894, Center for Psychiatry and Neuroscience, INSERM, Université Paris Descartes, Paris, France.
[21]
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.;Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
[22]
Boston University School of Medicine, Boston, Massachusetts, USA.;Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
[23]
Icelandic Heart Association, Kopavogur, Iceland.;Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
[24]
Institute for Systems Biology, Seattle, Washington, USA.
[25]
School of Biotechnology, Dublin City University, Dublin, Ireland.
[26]
Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
[27]
Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IFIMAV), Santander, Spain.
[28]
Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
[29]
Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas, USA.
[30]
Departments of Medicine, Geriatrics, Gerontology and Neurology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
[31]
Centre Hospitalier du Rouvray, Sotteville les Rouen, France.;INSERM U1079, Rouen University, IRIB, Normandy University, Rouen, France.
[32]
Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.;Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
[33]
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
[34]
Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.;Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
[35]
Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
[36]
Department of Medicine, University of Washington, Seattle, Washington, USA.
[37]
Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
[38]
Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
[39]
Neurodegenerative Disease Unit, Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
[40]
Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK.
[41]
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
[42]
Geriatric Medicine-Memory Unit and Rare Disease Centre, University of Bari Aldo Moro, Bari, Italy.
[43]
Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
[44]
Geriatric Unit and Gerontology-Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
[45]
Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
[46]
Framingham Heart Study, Framingham, Massachusetts, USA.;Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
[47]
INSERM U1079, Rouen University, IRIB, Normandy University, Rouen, France.;Department of Neurology, Rouen University Hospital, Rouen, France.
[48]
Department of Neurology, University Hospital La Paz, Universidad Autónoma de Madrid, Madrid, Spain.;Instituto de Investigación Sanitaria Hospital la Paz (IdiPAZ), Madrid, Spain.;Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
[49]
Boston University School of Medicine, Boston, Massachusetts, USA.;Framingham Heart Study, Framingham, Massachusetts, USA.;National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
[50]
Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, Florida, USA.
[51]
Department of Neuroscience, University of Parma, Parma, Italy.;Center for Cognitive Disorders AUSL, Parma, Italy.
[52]
Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany.
[53]
Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
[54]
AXA Research Fund and UPMC Chair, Paris, France.;Sorbonne Universités, Université Pierre et Marie Curie, Paris, France.;Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A) and Institut du Cerveau et de la Moelle Épinière (ICM), Département de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris, France.
[55]
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, USA.
[56]
Centre Hospitalier Universitaire de Lille, Epidemiology and Public Health Department, Lille, France.;INSERM UMRS 1171, CNR-Maj, Lille, France.
[57]
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA.
[58]
Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
[59]
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
[60]
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.
[61]
Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA.
[62]
Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.
[63]
Icelandic Heart Association, Kopavogur, Iceland.;Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland.
[64]
National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, USA.
[65]
Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK.
[66]
Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria.
[67]
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.;Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.
[68]
Department of Neurology, Catholic University of Rome, Rome, Italy.
[69]
Institute of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria.
[70]
Alzheimer's Disease and Memory Disorders Center, Baylor College of Medicine, Houston, Texas, USA.
[71]
Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy.
[72]
Department of Neurology, University of Washington, Seattle, Washington, USA.;Department of Epidemiology, University of Washington, Seattle, Washington, USA.
[73]
Office of Strategy and Measurement, University of North Texas Health Science Center, Fort Worth, Texas, USA.
[74]
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.;Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
[75]
C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
[76]
Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA.
[77]
Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
[78]
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.;Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.;Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.
[79]
Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.;Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
[80]
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.;Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, USA.
[81]
Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
[82]
Department of Mathematics and Statistics, Utah State University, Logan, Utah, USA.
[83]
Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.;Memory Unit, Department of Neurology, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona, Spain.
[84]
Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.;Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.
[85]
Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
[86]
INSERM U558, University of Toulouse, Toulouse, France.
[87]
Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
[88]
Elderly and Psychiatric Disorders Department, Medical University of Lodz, Lodz, Poland.
[89]
Department of Health Sciences, Psychiatry for the Elderly, University of Leicester, Leicester, UK.
[90]
Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.
[91]
Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy.
[92]
Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
[93]
Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.;Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain.
[94]
Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy.
[95]
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.
[96]
NEUROFARBA (Department of Neuroscience, Psychology, Drug Research and Child Health), University of Florence, Florence, Italy.;IRCCS 'Don Carlo Gnocchi', Florence, Italy.
[97]
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.
[98]
Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany.
[99]
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Associazione Oasi Maria Santissima Srl, Troina, Italy.
[100]
Mercers Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland.
[101]
Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK.
[102]
Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.;Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor Healthcare System (VAAAHS), Ann Arbor, Michigan, USA.;Michigan Alzheimer Disease Center, Ann Arbor, Michigan, USA.
[103]
Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.;Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA.;Department of Neurology, Indiana University, Indianapolis, Indiana, USA.;Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, Indiana, USA.
[104]
Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
[105]
Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, Wisconsin, USA.;Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA.;Wisconsin Alzheimer's Disease Research Center, Madison, Wisconsin, USA.
[106]
Department of Medicine (Genetics Program), Boston University, Boston, Massachusetts, USA.
[107]
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.;Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, USA.;Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
[108]
Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, Arizona, USA.
[109]
Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
[110]
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.;Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
[111]
Department of Neurology, University of Washington, Seattle, Washington, USA.;VA Puget Sound Health Care System/GRECC, Seattle, Washington, USA.
[112]
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
[113]
Swedish Medical Center, Seattle, Washington, USA.
[114]
Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
[115]
Department of Medicine, Duke University, Durham, North Carolina, USA.
[116]
University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, Kansas, USA.
[117]
Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA.;Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA.;Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA.
[118]
Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USA.
[119]
USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, Florida, USA.
[120]
Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
[121]
Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA.;Wisconsin Alzheimer's Disease Research Center, Madison, Wisconsin, USA.
[122]
Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA.
[123]
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
[124]
Department of Neurology, University of Southern California, Los Angeles, California, USA.
[125]
Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA.;Department of Neurology, Ralph H. Johnson VA Medical Center, Charleston, South Carolina, USA.
[126]
Department of Neurology, University of California, Irvine, Irvine, California, USA.
[127]
Department of Neurology, University of California, Davis, Sacramento, California, USA.
[128]
Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California, USA.
[129]
Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Florida, USA.
[130]
Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA.
[131]
Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA.
[132]
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
[133]
Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, Kentucky, USA.
[134]
Department of Neurology, Indiana University, Indianapolis, Indiana, USA.
[135]
Department of Psychiatry, New York University, New York, New York, USA.
[136]
Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.
[137]
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA.;Emory Alzheimer's Disease Center, Emory University, Atlanta, Georgia, USA.
[138]
Neurogenetics Program, University of California, Los Angeles, Los Angeles, California, USA.
[139]
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.;Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
[140]
Division of Genetics, Department of Medicine and Partners Center for Personalized Genetic Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
[141]
Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.
[142]
Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
[143]
Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
[144]
Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.
[145]
Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA.
[146]
Department of Pathology, Duke University, Durham, North Carolina, USA.
[147]
Department of Genome Sciences, University of Washington, Seattle, Washington, USA.;Department of Medicine (Medical Genetics), University of Washington, Seattle, Washington, USA.
[148]
Sanders-Brown Center on Aging, College of Public Health, Department of Epidemiology, University of Kentucky, Lexington, Kentucky, USA.
[149]
Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, California, USA.
[150]
Department of Medicine (Genetics Program), Boston University, Boston, Massachusetts, USA.;Department of Biostatistics, Boston University, Boston, Massachusetts, USA.;Department of Ophthalmology, Boston University, Boston, Massachusetts, USA.
[151]
Department of Neurology, Oregon Health &Science University, Portland, Oregon, USA.;Department of Neurology, Portland Veterans Affairs Medical Center, Portland, Oregon, USA.
[152]
Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, California, USA.
[153]
Department of Neurology, Boston University, Boston, Massachusetts, USA.;Department of Pathology, Boston University, Boston, Massachusetts, USA.
[154]
Department of Neuropsychology, University of California, San Francisco, San Francisco, California, USA.
[155]
Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California, USA.
[156]
Department of Neurology, Emory University, Atlanta, Georgia, USA.
[157]
Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, Ohio, USA.
[158]
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.;VA Puget Sound Health Care System/GRECC, Seattle, Washington, USA.
[159]
Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
[160]
Department of Biostatistics, Boston University, Boston, Massachusetts, USA.
[161]
Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA.
[162]
Department of Medicine-Pulmonary, New York University, New York, New York, USA.
[163]
Department of Neurology, University of Miami, Miami, Florida, USA.
[164]
Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.;Department of Pathology, University of California, San Diego, La Jolla, California, USA.
[165]
School of Nursing Northwest Research Group on Aging, University of Washington, Seattle, Washington, USA.
[166]
Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.;Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
[167]
Department of Pathology, University of Southern California, Los Angeles, California, USA.
[168]
Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USA.;Department of Neurology, Washington University, St. Louis, Missouri, USA.
[169]
Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA.;Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA.
[170]
Internal Medicine, Division of Geriatrics, University of North Texas Health Science Center, Fort Worth, Texas, USA.
[171]
Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
[172]
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
[173]
Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.;Michigan Alzheimer Disease Center, Ann Arbor, Michigan, USA.
[174]
Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.
[175]
Department of Psychiatry, New York University, New York, New York, USA.;Alzheimer's Disease Center, New York University, New York, New York, USA.
[176]
Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.;Department of Neurology, Columbia University, New York, New York, USA.;Department of Epidemiology, Columbia University, New York, New York, USA.
[177]
Department of Neurology, University of California, Los Angeles, Los Angeles, California, USA.
[178]
Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.
[179]
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
[180]
Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
[181]
Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA.;Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, Indiana, USA.
[182]
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.;Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.;Department of Pathology (Neuropathology), Rush University Medical Center, Chicago, Illinois, USA.
[183]
Department of Neurology, University of Southern California, Los Angeles, California, USA.;Department of Psychiatry, University of Southern California, Los Angeles, California, USA.
[184]
Department of Pathology, University of Washington, Seattle, Washington, USA.
[185]
Department of Neurology, Boston University, Boston, Massachusetts, USA.
[186]
Translational Medicine, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
[187]
Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
[188]
Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
[189]
Sanders-Brown Center on Aging, Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky, USA.
[190]
Department of Neurology, University of California, Los Angeles, Los Angeles, California, USA.;Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA.
[191]
Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University, New York, New York, USA.
[192]
Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.;Department of Psychiatry, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
[193]
Department of Medicine, Duke University, Durham, North Carolina, USA.;Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA.
[194]
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
[195]
Department of Pathology, Oregon Health &Science University, Portland, Oregon, USA.
[196]
Evelyn F. McKnight Brain Institute, Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
[197]
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.;Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
[198]
Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.;Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium.
[199]
Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium.;Laboratory for Cognitive Neurology, Department of Neurology, University of Leuven, Leuven, Belgium.
[200]
Department of Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden.;Department of Neurobiology, Care Sciences and Society, KIADRC, Karolinska Institutet, Stockholm, Sweden.
[201]
Department of Neurology, Kuopio University Hospital, Kuopio, Finland.;Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.
[202]
CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France.
[203]
INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.;Institut Pasteur de Lille, Lille, France.;University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.;University Paris Descartes, EA 4468, AP-HP, Hôpital Broca, Geriatrics Department, Paris, France.
[204]
University Paris Descartes, EA 4468, AP-HP, Hôpital Broca, Geriatrics Department, Paris, France.
[205]
University of Bordeaux, Neuroepidemiology, Bordeaux, France.;INSERM, Neuroepidemiology, UMR 897, Bordeaux, France.
[206]
INSERM U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.;AP-HP, Department of Genetics, Pitié-Salpêtrière Hospital, Paris, France.
[207]
INSERM U1061, La Colombière Hospital, Montpellier, France.
[208]
Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Département de Neurologie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.;Institut des Neurosciences Translationnelles de Paris (IHU-A-ICM), Institut du Cerveau et de la Moelle Épinière (ICM), Paris, France.;INSERM, CNRS, UMRS 975, Institut du Cerveau et de la Moelle Épinière (ICM), Paris, France.;Sorbonne Universités, Université Pierre et Marie Curie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.
[209]
Boston University School of Medicine, Boston, Massachusetts, USA.
[210]
Department of Epidemiology, University of Washington, Seattle, Washington, USA.;Department of Family Medicine, University of Washington, Seattle, Washington, USA.
[211]
Department of Epidemiology, University of Washington, Seattle, Washington, USA.
[212]
Icelandic Heart Association, Kopavogur, Iceland.;Centre for Public Health, University of Iceland, Reykjavik, Iceland.
[213]
Department of Medicine, University of Washington, Seattle, Washington, USA.;Group Health Research Institute, Group Health, Seattle, Washington, USA.
[214]
Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
[215]
Instituto de Investigación Sanitaria Hospital la Paz (IdiPAZ), Madrid, Spain.;Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.;Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.
[216]
Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain.
[217]
School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA.;Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.
[218]
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.;Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.;Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands.
[219]
Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA.;Arizona Alzheimer's Consortium, Phoenix, Arizona, USA.;Banner Alzheimer's Institute, Phoenix, Arizona, USA.;Department of Psychiatry, University of Arizona, Phoenix, Arizona, USA.
[220]
Framingham Heart Study, Framingham, Massachusetts, USA.
[221]
Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
[222]
Departments of Psychiatry, Medicine, and Family and Community Medicine and South Texas Veterans Health Administration Geriatric Research Education and Clinical Center (GRECC), University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
[223]
Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany.;German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
[224]
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA.
[225]
Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.;Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
[226]
Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy.
[227]
PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, USA.
[228]
Institute of Neurology, Catholic University of Sacred Hearth, Rome, Italy.
[229]
Departments of Neurology, Pharmacology, and Neuroscience, Texas Tech University Health Science Center, Lubbock, Texas, USA.
[230]
Department of Psychiatry, Charité University Medicine, Berlin, Germany.
[231]
Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
[232]
Institute of Public Health, University of Cambridge, Cambridge, UK.
[233]
Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
[234]
Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK.;Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal.
[235]
Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
[236]
Institute of Brain, Behaviour and Mental Health, Clinical and Cognitive Neuroscience Research Group, University of Manchester, Manchester, UK.
[237]
3rd Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
[238]
Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK.
[239]
Department of Psychiatry, University of Oxford, Oxford, UK.
[240]
Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA.
[241]
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.;Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.;Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy.
[242]
VA Puget Sound Health Care System/GRECC, Seattle, Washington, USA.
[243]
Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, Florida, USA.;Florida Alzheimer's Disease Research Center, Gainesville, Florida, USA.
[244]
Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.;Department of Neurobiology, Care Sciences and Society, KIADRC, Karolinska Institutet, Stockholm, Sweden.
[245]
Center for Translational and Systems Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, New York, USA.
[246]
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.;Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.;Department of Epidemiology, University of Washington, Seattle, Washington, USA.;Department of Health Services, University of Washington, Seattle, Washington, USA.
[247]
Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Département de Neurologie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.;Memory Research and Resources Center, CMRR of Montpellier, Department of Neurology, Hospital Gui de Chauliac, Montpellier, France.;Department of Neurology, Montpellier University, Montpellier, France.
[248]
Memory Research and Resources Center, CMRR de Bordeaux, Bordeaux, France.
[249]
Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.;Neurogenetics Laboratory, Division of Neurosciences, Centre for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain.;Department of Neurology, Complejo Asistencial Universitario de Palencia, Palencia, Spain.
[250]
Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
[251]
Departments of Biology and Neuroscience, Brigham Young University, Provo, Utah, USA.
[252]
Boston University School of Medicine, Boston, Massachusetts, USA.;Department of Medicine (Genetics Program), Boston University, Boston, Massachusetts, USA.;Department of Biostatistics, Boston University, Boston, Massachusetts, USA.;Department of Ophthalmology, Boston University, Boston, Massachusetts, USA.;Department of Neurology, Boston University, Boston, Massachusetts, USA.
[253]
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.;Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
[254]
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA.
[255]
INSERM U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.;University of Bordeaux, Neuroepidemiology, UMR 897, Bordeaux, France.
[256]
INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.;Institut Pasteur de Lille, Lille, France.;University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.;Centre Hospitalier Universitaire de Lille, Epidemiology and Public Health Department, Lille, France.
[257]
Institute of Human Genetics, University of Bonn, Bonn, Germany.;Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.;Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.
[258]
医学主题词
衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);阿尔茨海默病(Alzheimer Disease);氨基酸序列(Amino Acid Sequence);病例对照研究(Case-Control Studies);基因表达谱(Gene Expression Profiling);基因频率(Gene Frequency);疾病遗传易感性(Genetic Predisposition to Disease);基因型(Genotype);人类(Humans);免疫, 先天(Immunity, Innate);连锁不平衡(Linkage Disequilibrium);膜糖蛋白类(Membrane Glycoproteins);小神经胶质细胞(Microglia);比值比(Odds Ratio);磷脂酶Cγ(Phospholipase C gamma);多态性, 单核苷酸(Polymorphism, Single Nucleotide);受体, 免疫(Receptors, Immunologic);序列同源性, 氨基酸(Sequence Homology, Amino Acid)
DOI
10.1038/ng.3916
PMID
28714976
发布时间
2025-05-30
- 浏览77
Nature genetics
Nature genetics
1373-1384页
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