Fusion to Flaviviral Leader Peptide Targets HIV-1 Reverse Transcriptase for Secretion and Reduces Its Enzymatic Activity and Ability to Induce Oxidative Stress but Has No Major Effects on Its Immunogenic Performance in DNA-Immunized Mice.

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作者： Anastasia,Latanova ^[1] ; Stefan,Petkov ^[2] ; Yulia,Kuzmenko ^[3] ; Athina,Kilpeläinen ^[3] ; Alexander,Ivanov ^[1] ; Olga,Smirnova ^[3] ; Olga,Krotova ^[1] ; Sergey,Korolev ^[1] ; Jorma,Hinkula ^[1] ; Vadim,Karpov ^[2] ; Maria,Isaguliants ^[4] ; Elizaveta,Starodubova ^[5]

作者单位： Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia. ^[1] Gamaleja Research Center of Epidemiology and Microbiology, Moscow, Russia. ^[2] Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. ^[3] Chemistry Department, Belozersky Research Institute of Physico-Chemical Biology of Lomonosov Moscow State University, Moscow, Russia. ^[4] Linköping University, Linköping, Sweden. ^[5] Riga Stradins University, Riga, Latvia. ^[6] M.P. Chumakov Institute of Poliomyelitis and Viral Encephalities, Russian Academy of Sciences, Moscow, Russia. ^[7]

主题词艾滋病疫苗(AIDS Vaccines);动物(Animals);细胞系(Cell Line);女(雌)性(Female);颗粒酶类(Granzymes);HIV抗体(HIV Antibodies);HIV逆转录酶(HIV Reverse Transcriptase);HIV-1(HIV-1);人类(Humans);干扰素γ(Interferon-gamma);白细胞介素2(Interleukin-2);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);氧化性应激(Oxidative Stress);蛋白分选信号(Protein Sorting Signals);重组融合蛋白质类(Recombinant Fusion Proteins);疫苗, DNA(Vaccines, DNA)

DOI 10.1155/2017/7407136

PMID 28717654

发布时间 2018-11-13

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Journal of immunology research

2017年2017卷

7407136页

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Fusion to Flaviviral Leader Peptide Targets HIV-1 Reverse Transcriptase for Secretion and Reduces Its Enzymatic Activity and Ability to Induce Oxidative Stress but Has No Major Effects on Its Immunogenic Performance in DNA-Immunized Mice.

Journal of immunology research

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Journal of immunology research

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Fusion to Flaviviral Leader Peptide Targets HIV-1 Reverse Transcriptase for Secretion and Reduces Its Enzymatic Activity and Ability to Induce Oxidative Stress but Has No Major Effects on Its Immunogenic Performance in DNA-Immunized Mice.

Journal of immunology research

相似文献

Journal of immunology research

相关期刊

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