An autophagy-driven pathway of ATP secretion supports the aggressive phenotype of BRAF<sup>V600E</sup> inhibitor-resistant metastatic melanoma cells.

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第一作者： Shaun,Martin

第一单位： a Laboratory for Cell Death Research and Therapy, Department of Cellular and Molecular Medicine , University of Leuven (KU Leuven) , Campus Gasthuisberg , Leuven , Belgium.;b Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine , University of Leuven (KU Leuven) , Campus Gasthuisberg, Leuven , Belgium.

作者： Shaun,Martin ^[1] ; Aleksandra M,Dudek-Peric ^[2] ; Abhishek D,Garg ^[2] ; Heleen,Roose ^[3] ; Seyma,Demirsoy ^[2] ; Sofie,Van Eygen ^[2] ; Freya,Mertens ^[3] ; Peter,Vangheluwe ^[4] ; Hugo,Vankelecom ^[3] ; Patrizia,Agostinis ^[2]

作者单位： a Laboratory for Cell Death Research and Therapy, Department of Cellular and Molecular Medicine , University of Leuven (KU Leuven) , Campus Gasthuisberg , Leuven , Belgium.;b Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine , University of Leuven (KU Leuven) , Campus Gasthuisberg, Leuven , Belgium. ^[1] a Laboratory for Cell Death Research and Therapy, Department of Cellular and Molecular Medicine , University of Leuven (KU Leuven) , Campus Gasthuisberg , Leuven , Belgium. ^[2] c Department of Development and Regeneration, Cluster Stem Cell Biology and Embryology , University of Leuven (KU Leuven) , Campus Gasthuisberg, Leuven , Belgium. ^[3] b Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine , University of Leuven (KU Leuven) , Campus Gasthuisberg, Leuven , Belgium. ^[4]

关键词 BRAFV600E inhibitor-resistance P2RX7 receptor Vemurafenib extracellular ATP invasion macroautophagy melanoma