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Nuclear mTOR acts as a transcriptional integrator of the androgen signaling pathway in prostate cancer.

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第一作者： Étienne,Audet-Walsh

第一单位： Goodman Cancer Research Centre, McGill University, Montréal, Québec H3A 1A3, Canada.

作者： Étienne,Audet-Walsh ^[1] ; Catherine R,Dufour ^[1] ; Tracey,Yee ^[1] ; Fatima Z,Zouanat ^[2] ; Ming,Yan ^[1] ; Georges,Kalloghlian ^[2] ; Mathieu,Vernier ^[1] ; Maxime,Caron ^[3] ; Guillaume,Bourque ^[4] ; Eleonora,Scarlata ^[2] ; Lucie,Hamel ^[2] ; Fadi,Brimo ^[5] ; Armen G,Aprikian ^[6] ; Jacques,Lapointe ^[7] ; Simone,Chevalier ^[8] ; Vincent,Giguère ^[9]

作者单位： Goodman Cancer Research Centre, McGill University, Montréal, Québec H3A 1A3, Canada. ^[1] Urologic Oncology Research Group, Cancer Research Program, Research Institute of the McGill University Health Centre (MUHC), Montréal, Québec H4A 3J1, Canada. ^[2] Génome Québec Innovation Centre, McGill University, Montréal, Québec H3A 0G1, Canada. ^[3] Génome Québec Innovation Centre, McGill University, Montréal, Québec H3A 0G1, Canada.;Department of Human Genetics, McGill University, Montréal, Québec H3A 1A3, Canada. ^[4] Department of Human Genetics, McGill University, Montréal, Québec H3A 1A3, Canada. ^[5] Urologic Oncology Research Group, Cancer Research Program, Research Institute of the McGill University Health Centre (MUHC), Montréal, Québec H4A 3J1, Canada.;Department of Pathology, McGill University and MUHC, Montréal, Québec H4A 3J1, Canada. ^[6] Department of Surgery (Urology), McGill University and MUHC, Montréal, Québec H4A 3J1, Canada.;Department of Oncology, McGill University and MUHC, Montréal, Québec H4A 3J1, Canada. ^[7] Urologic Oncology Research Group, Cancer Research Program, Research Institute of the McGill University Health Centre (MUHC), Montréal, Québec H4A 3J1, Canada.;Department of Pathology, McGill University and MUHC, Montréal, Québec H4A 3J1, Canada.;Department of Medicine, McGill University, Montréal, Québec H3G 1Y6, Canada.;Department of Oncology, McGill University, Montréal, Québec H3G 1Y6, Canada. ^[8] Goodman Cancer Research Centre, McGill University, Montréal, Québec H3A 1A3, Canada.;Department of Medicine, McGill University, Montréal, Québec H3G 1Y6, Canada.;Department of Oncology, McGill University, Montréal, Québec H3G 1Y6, Canada.;Department of Biochemistry, McGill University, Montréal, Québec H3G 1Y6, Canada. ^[9]

关键词 CRPC ChIP-seq androgen receptor energy metabolism nuclear receptor steroid