Modulation of the interaction between human P450 3A4 and B. megaterium reductase via engineered loops.

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作者： Silvia,Castrignanò ^[1] ; Serena,D'Avino ^[1] ; Giovanna,Di Nardo ^[1] ; Gianluca,Catucci ^[1] ; Sheila J,Sadeghi ^[1] ; Gianfranco,Gilardi ^[2]

作者单位： Department of Life Sciences and Systems Biology, University of Torino, Via Accademia Albertina 13, Torino, Italy. ^[1] Department of Life Sciences and Systems Biology, University of Torino, Via Accademia Albertina 13, Torino, Italy. Electronic address: gianfranco.gilardi@unito.it. ^[2]

关键词 Chimeric enzymes Cytochrome P450 3A4 Drug-drug interaction Molecular lego

主题词巨大芽孢杆菌(Bacillus megaterium);细菌蛋白质类(Bacterial Proteins);结合部位(Binding Sites);细胞色素P-450 CYP3A(Cytochrome P-450 CYP3A);基因表达(Gene Expression);人类(Humans);酮康唑(Ketoconazole);动力学(Kinetics);配体(Ligands);NADPH高铁血红素蛋白还原酶(NADPH-Ferrihemoprotein Reductase);蛋白质结合(Protein Binding);蛋白质工程(Protein Engineering);蛋白质相互作用域和基序(Protein Interaction Domains and Motifs);重组融合蛋白质类(Recombinant Fusion Proteins);构效关系(Structure-Activity Relationship);底物特异性(Substrate Specificity);睾酮(Testosterone)

DOI 10.1016/j.bbapap.2017.07.009

PMID 28734977

发布时间 2018-12-11

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Biochimica et biophysica acta. Proteins and proteomics

2018年1866卷1期

116-125页

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Modulation of the interaction between human P450 3A4 and B. megaterium reductase via engineered loops.

Biochimica et biophysica acta. Proteins and proteomics

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Biochimica et biophysica acta. Proteins and proteomics

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Modulation of the interaction between human P450 3A4 and B. megaterium reductase via engineered loops.

Biochimica et biophysica acta. Proteins and proteomics

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Biochimica et biophysica acta. Proteins and proteomics

相关期刊

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