首页> BMC biology> Charged residues next to transmembrane regions revisited: "Positive-inside rule" is complemented by the "negative inside depletion/outside enrichment rule".

Charged residues next to transmembrane regions revisited: "Positive-inside rule" is complemented by the "negative inside depletion/outside enrichment rule".

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第一作者： James Alexander,Baker

第一单位： Bioinformatics Institute, Agency for Science Technology and Research (A*STAR), 30 Biopolis Street #07-01, Matrix, Singapore, 138671, Singapore.;School of Chemistry, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK.

作者： James Alexander,Baker ^[1] ; Wing-Cheong,Wong ^[2] ; Birgit,Eisenhaber ^[2] ; Jim,Warwicker ^[3] ; Frank,Eisenhaber ^[4]

作者单位： Bioinformatics Institute, Agency for Science Technology and Research (A*STAR), 30 Biopolis Street #07-01, Matrix, Singapore, 138671, Singapore.;School of Chemistry, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK. ^[1] Bioinformatics Institute, Agency for Science Technology and Research (A*STAR), 30 Biopolis Street #07-01, Matrix, Singapore, 138671, Singapore. ^[2] School of Chemistry, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK. j.warwicker@manchester.ac.uk. ^[3] Bioinformatics Institute, Agency for Science Technology and Research (A*STAR), 30 Biopolis Street #07-01, Matrix, Singapore, 138671, Singapore. franke@bii.a-star.edu.sg.;School of Computer Engineering (SCE), Nanyang Technological University (NTU), 50 Nanyang Drive, Singapore, 637553, Singapore. franke@bii.a-star.edu.sg. ^[4]

关键词 Amino acid distribution Genome-wide statistical study Membrane protein Negative-not-inside/negative-outside rule Protein topology prediction Proteomics Transmembrane helix Transmembrane region prediction

医学主题词细胞膜(Cell Membrane);膜蛋白质类(Membrane Proteins);模型, 分子(Models, Molecular);蛋白质构象(Protein Conformation)

DOI 10.1186/s12915-017-0404-4

PMID 28738801

发布时间 2018-11-13

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