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In-situ tissue regeneration through SDF-1α driven cell recruitment and stiffness-mediated bone regeneration in a critical-sized segmental femoral defect.

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第一作者： Amaia,Cipitria

第一单位： Julius Wolff Institute & Center for Musculoskeletal Surgery, Charité - Universitätsmedizin Berlin, 13353 Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies, Charité - Universitätsmedizin Berlin, 13353 Berlin, Germany. Electronic address: amaia.cipitria@charite.de.

作者： Amaia,Cipitria ^[1] ; Kathrin,Boettcher ^[2] ; Sophia,Schoenhals ^[2] ; Daniela S,Garske ^[2] ; Katharina,Schmidt-Bleek ^[2] ; Agnes,Ellinghaus ^[2] ; Anke,Dienelt ^[3] ; Anja,Peters ^[2] ; Manav,Mehta ^[4] ; Christopher M,Madl ^[5] ; Nathaniel,Huebsch ^[6] ; David J,Mooney ^[6] ; Georg N,Duda ^[3]

作者单位： Julius Wolff Institute & Center for Musculoskeletal Surgery, Charité - Universitätsmedizin Berlin, 13353 Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies, Charité - Universitätsmedizin Berlin, 13353 Berlin, Germany. Electronic address: amaia.cipitria@charite.de. ^[1] Julius Wolff Institute & Center for Musculoskeletal Surgery, Charité - Universitätsmedizin Berlin, 13353 Berlin, Germany. ^[2] Julius Wolff Institute & Center for Musculoskeletal Surgery, Charité - Universitätsmedizin Berlin, 13353 Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies, Charité - Universitätsmedizin Berlin, 13353 Berlin, Germany. ^[3] Julius Wolff Institute & Center for Musculoskeletal Surgery, Charité - Universitätsmedizin Berlin, 13353 Berlin, Germany; School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. ^[4] School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA. ^[5] School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. ^[6]

关键词 Critical-sized segmental femoral defect Endogenous cell recruitment Stiffness-mediated osteogenic differentiation in-vivo Stromal cell-derived factor-1α (SDF-1α)Void-forming alginate hydrogels