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Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint.

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第一作者： Pietro,Roversi

第一单位： Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom; pietro.roversi@bioch.ox.ac.uk nicole.zitzmann@bioch.ox.ac.uk.

作者： Pietro,Roversi ^[1] ; Lucia,Marti ^[2] ; Alessandro T,Caputo ^[3] ; Dominic S,Alonzi ^[3] ; Johan C,Hill ^[3] ; Kyle C,Dent ^[4] ; Abhinav,Kumar ^[3] ; Mikail D,Levasseur ^[3] ; Andrea,Lia ^[5] ; Thomas,Waksman ^[3] ; Souradeep,Basu ^[3] ; Yentli,Soto Albrecht ^[3] ; Kristin,Qian ^[3] ; James Patrick,McIvor ^[3] ; Colette B,Lipp ^[3] ; Dritan,Siliqi ^[6] ; Snežana,Vasiljević ^[3] ; Shabaz,Mohammed ^[3] ; Petra,Lukacik ^[4] ; Martin A,Walsh ^[4] ; Angelo,Santino ^[2] ; Nicole,Zitzmann ^[1]

作者单位： Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom; pietro.roversi@bioch.ox.ac.uk nicole.zitzmann@bioch.ox.ac.uk. ^[1] Institute of Sciences of Food Production, Consiglio Nazionale delle Ricerche (CNR) Unit of Lecce, I-73100 Lecce, Italy. ^[2] Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom. ^[3] Diamond Light Source and Research Complex at Harwell, Didcot OX11 0DE, United Kingdom. ^[4] Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.;Institute of Sciences of Food Production, Consiglio Nazionale delle Ricerche (CNR) Unit of Lecce, I-73100 Lecce, Italy. ^[5] Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, I-70126 Bari, Italy. ^[6]

关键词 UDP-glucose glycoprotein glucosyltransferase UGGT endoplasmic reticulum eukaryotic secretion glycoprotein folding