TCR Signal Quality Modulates Fate Decisions of Single CD4<sup>+</sup> T Cells in a Probabilistic Manner.

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作者： Yi-Li,Cho ^[1] ; Michael,Flossdorf ^[1] ; Lorenz,Kretschmer ^[1] ; Thomas,Höfer ^[2] ; Dirk H,Busch ^[3] ; Veit R,Buchholz ^[4]

作者单位： Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), 81675 Munich, Germany. ^[1] Division of Theoretical Systems Biology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; BioQuant Center, University of Heidelberg, 69120 Heidelberg, Germany. ^[2] Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), 81675 Munich, Germany; Focus Group "Clinical Cell Processing and Purification," Institute for Advanced Study, TUM, 85748 Munich, Germany; National Center for Infection Research (DZIF), 81675 Munich, Germany. Electronic address: dirk.busch@tum.de. ^[3] Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), 81675 Munich, Germany. Electronic address: veit.buchholz@tum.de. ^[4]

关键词 CD4 T?cells TCR avidity TCR binding strength TCR signal quality computational modelling differentiation immunological memory probabilistic regulation single-cell in?vivo fate mapping