Regions of common inter-individual DNA methylation differences in human monocytes: genetic basis and potential function.

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第一作者： Christopher,Schröder

第一单位： Genome Informatics, Institute of Human Genetics, University of Duisburg-Essen, University Hospital Essen, Essen, Germany.

作者： Christopher,Schröder ^[1] ; Elsa,Leitão ^[2] ; Stefan,Wallner ^[3] ; Gerd,Schmitz ^[3] ; Ludger,Klein-Hitpass ^[4] ; Anupam,Sinha ^[5] ; Karl-Heinz,Jöckel ^[6] ; Stefanie,Heilmann-Heimbach ^[7] ; Per,Hoffmann ^[8] ; Markus M,Nöthen ^[7] ; Michael,Steffens ^[8] ; Peter,Ebert ^[9] ; Sven,Rahmann ^[10] ; Bernhard,Horsthemke ^[7]

作者单位： Genome Informatics, Institute of Human Genetics, University of Duisburg-Essen, University Hospital Essen, Essen, Germany. ^[1] Institute of Human Genetics, University of Duisburg-Essen, University Hospital Essen, Hufelandstraße 55, 45147, Essen, Germany. ^[2] Institute for Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany. ^[3] Institute of Cell Biology, University Hospital Essen, Essen, Germany. ^[4] Institute of Clinical Molecular Biology, Kiel University, University Hospital, Kiel, Germany. ^[5] Institute of Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany. ^[6] Institute of Human Genetics, School of Medicine, University Hospital of Bonn, University of Bonn, Bonn, Germany. ^[7] Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany. ^[8] Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland. ^[9] Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland. ^[10] Research Division, Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany. ^[11] Max Planck Institute for Informatics, Saarland Informatics Campus, Saarbrücken, Germany. ^[12] Saarbrücken Graduate School of Computer Science, Saarland Informatics Campus, Saarbrücken, Germany. ^[13] Institute of Human Genetics, University of Duisburg-Essen, University Hospital Essen, Hufelandstraße 55, 45147, Essen, Germany. bernhard.horsthemke@uni-due.de. ^[14]

关键词 Allele-specific methylation DNA methylation Differentially methylated regions Genome-wide association study Haplotype Inter-individual variability Methylation array SNP genotyping Whole genome bisulfite sequencing

主题词细胞, 培养的(Cells, Cultured);染色质(Chromatin);CpG岛(CpG Islands);DNA甲基化(DNA Methylation);人类(Humans);单核细胞(Monocytes);多态性, 单核苷酸(Polymorphism, Single Nucleotide)

DOI 10.1186/s13072-017-0144-2

PMID 28747224

发布时间 2018-11-13

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