BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease.

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作者： Federica,Prati ^[1] ; Giovanni,Bottegoni ^[2] ; Maria Laura,Bolognesi ^[3] ; Andrea,Cavalli ^[4]

作者单位： Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee, DD1 5EH, Scotland, U.K. ^[1] CompuNet, Istituto Italiano di Tecnologia , Via Morego 30, 16163 Genova, Italy. ^[2] Heptares Therapeutics Ltd. , BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, U.K. ^[3] Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna , Via Belmeloro 6, 40126 Bologna, Italy. ^[4]

主题词阿尔茨海默病(Alzheimer Disease);淀粉样前体蛋白分泌酶类(Amyloid Precursor Protein Secretases);动物(Animals);人类(Humans);分子靶向治疗(Molecular Targeted Therapy);蛋白酶抑制药(Protease Inhibitors)

DOI 10.1021/acs.jmedchem.7b00393

PMID 28749667

发布时间 2019-02-25

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