Influenza virus NS1 protein mutations at position 171 impact innate interferon responses by respiratory epithelial cells.

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作者： Ewan P,Plant ^[1] ; Natalia A,Ilyushina ^[2] ; Faruk,Sheikh ^[3] ; Raymond P,Donnelly ^[4] ; Zhiping,Ye ^[5]

作者单位： Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, USA. Electronic address: Ewan.Plant@fda.hhs.gov. ^[1] Division of Biotechnology Research and Review II, Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, USA. Electronic address: Natalia.Ilyushina@fda.hhs.gov. ^[2] Division of Biotechnology Research and Review II, Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, USA. Electronic address: Faruk.Sheikh@fda.hhs.gov. ^[3] Division of Biotechnology Research and Review II, Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, USA. Electronic address: Raymond.Donnelly@fda.hhs.gov. ^[4] Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, USA. Electronic address: Zhiping.Ye@fda.hhs.gov. ^[5]

关键词 A459 cells ISG Influenza Interferon NS1 STAT1

主题词氨基酸特征结构(Amino Acid Motifs);上皮细胞(Epithelial Cells);宿主与病原体相互作用(Host-Pathogen Interactions);人类(Humans);免疫, 先天(Immunity, Innate);流感病毒A型, H1N1亚型(Influenza A Virus, H1N1 Subtype);流感, 人(Influenza, Human);干扰素类(Interferons);突变(Mutation);STAT1转录因子(STAT1 Transcription Factor);病毒非结构蛋白质类(Viral Nonstructural Proteins);病毒复制(Virus Replication)

DOI 10.1016/j.virusres.2017.07.021

PMID 28757142

发布时间 2018-02-09

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Virus research

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Influenza virus NS1 protein mutations at position 171 impact innate interferon responses by respiratory epithelial cells.

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Influenza virus NS1 protein mutations at position 171 impact innate interferon responses by respiratory epithelial cells.

Virus research

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Virus research

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