The Binding Effect of Proteins on Medications and Its Impact on Electrochemical Sensing: Antipsychotic Clozapine as a Case Study.

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作者： George E,Banis ^[1] ; Thomas,Winkler ^[2] ; Patricia,Barton ^[3] ; Sheryl E,Chocron ^[4] ; Eunkyoung,Kim ^[5] ; Deanna L,Kelly ^[6] ; Gregory F,Payne ^[7] ; Hadar,Ben-Yoav ^[8] ; Reza,Ghodssi ^[9]

作者单位： Department of Bioengineering, University of Maryland, 2201 J.M. Patterson Hall, College Park, MD 20742, USA. gbanis@umd.edu. ^[1] Department of Bioengineering, University of Maryland, 2201 J.M. Patterson Hall, College Park, MD 20742, USA. winklert@kth.se. ^[2] Department of Bioengineering, University of Maryland, 2201 J.M. Patterson Hall, College Park, MD 20742, USA. pbarton@umd.edu. ^[3] Department of Bioengineering, University of Maryland, 2201 J.M. Patterson Hall, College Park, MD 20742, USA. sherylchb@gmail.com. ^[4] Institute for Bioscience and Biotechnology Research, University of Maryland, Suite 5115 Plant Sciences Building, College Park, MD 20742, USA. kimk@ibbr.umd.edu. ^[5] Maryland Psychiatric Research Center, University of Maryland School of Medicine, 655 W. Baltimore Street, Baltimore MD 21201, USA. dkelly@mprc.umaryland.edu. ^[6] Institute for Bioscience and Biotechnology Research, University of Maryland, Suite 5115 Plant Sciences Building, College Park, MD 20742, USA. gpayne@umd.edu. ^[7] Department of Biomedical Engineering, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel. benyoav@bgu.ac.il. ^[8] Department of Bioengineering, University of Maryland, 2201 J.M. Patterson Hall, College Park, MD 20742, USA. ghodssi@umd.edu. ^[9] Institute for Systems Research, University of Maryland, 2173 A.V. Williams Building, College Park, MD 20742, USA. ghodssi@umd.edu. ^[10]

关键词 albumin alpha-1 acid-glycoprotein clozapine electrochemistry ultrafiltration

DOI 10.3390/ph10030069

PMID 28763030

发布时间 2024-03-27

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