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首页> European journal of medicinal chemistry> Norepinephrine alkaloids as antiplasmodial agents: Synthesis of syncarpamide and insight into the structure-activity relationships of its analogues as antiplasmodial agents.

Norepinephrine alkaloids as antiplasmodial agents: Synthesis of syncarpamide and insight into the structure-activity relationships of its analogues as antiplasmodial agents.

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作者： Eswar K,Aratikatla ^[1] ; Tushar R,Valkute ^[2] ; Sunil K,Puri ^[3] ; Kumkum,Srivastava ^[3] ; Asish K,Bhattacharya ^[4]

作者单位： Division of Organic Chemistry, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune, 411 008, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-NCL, Pune, 411 008, India. ^[1] Division of Organic Chemistry, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune, 411 008, India. ^[2] Parasitology Division, CSIR-Central Drug Research Institute, Sector-10, Janakipuram Extension, Sitapur Road, Lucknow, 226 031, India. ^[3] Division of Organic Chemistry, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune, 411 008, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-NCL, Pune, 411 008, India. Electronic address: ak.bhattacharya@ncl.res.in. ^[4]

关键词 Antiplasmodial activity Cytotoxicity In?vitro activity In?vivo activity Natural products Norepinephrine alkaloids Syncarpamide Synthesis

主题词生物碱类(Alkaloids);抗疟药(Antimalarials);剂量效应关系, 药物(Dose-Response Relationship, Drug);分子结构(Molecular Structure);去甲肾上腺素(Norepinephrine);寄生虫敏感性试验(Parasitic Sensitivity Tests);恶性疟原虫(Plasmodium falciparum);芸香科(Rutaceae);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.ejmech.2017.07.052

PMID 28763644

发布时间 2017-09-29

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European journal of medicinal chemistry

1089-1105页

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